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AS1842856

Cat. No. M9069
AS1842856 Structure
Size Price Availability Quantity
10mg USD 140 In stock
50mg USD 460 In stock
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Quality Control
Biological Activity

AS1842856 potently inhibits human Foxo1 transactivation and reduces glucose production through the inhibition of glucose-6 phosphatase and phosphoenolpyruvate carboxykinase mRNA levels in a rat hepatic cell line. In vivo, Oral administration of AS1842856 to diabetic db/db mice leads to a drastic decrease in fasting plasma glucose level via the inhibition of hepatic gluconeogenic genes, whereas administration to normal mice has no effect on the fasting plasma glucose level. Treatment with AS1842856 also suppresses an increase in plasma glucose level caused by pyruvate injection in both normal and db/db mice.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 347.38
Formula C18H22FN3O3
CAS Number 836620-48-5
Purity 99.80%
Solubility DMSO: ≥ 6 mg/mL (Need ultrasonic and warming)
Storage at -20°C
References

Discovery of novel forkhead box O1 inhibitors for treating type 2 diabetes: improvement of fasting glycemia in diabetic db/db mice.
Nagashima T, et al. Mol Pharmacol. 2010 Nov;78(5):961-70. PMID: 20736318.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: AS1842856 supplier, Autophagy, inhibitors

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