Pivastatin calcium (Livalo) is a new member of the statin group. Like other statins, it is an inhibitor of hmG-COA reductase, an enzyme that catalyzes the first step in cholesterol synthesis. Most statins are metabolized in part by one or more liver cytochrome P450 enzymes, leading to an increased likelihood of complex interactions and problems with certain foods, such as grapefruit juice. Pivastatin appears to be a substrate for CYP2C9, rather than CYP3A4(a common source of interactions with other statins).
Pak J Pharm Sci. 2016 May;29(3 Suppl):1043-51.
Chromatographic resolution of drug analogues: 3-hydroxy-3-methylglutarylcoenzyme A reductase inhibitors (statins)
Pitavastatin Calcium purchased from AbMole
Molecular Weight | 880.98 |
Formula | C50H46CaF2N2O8 |
CAS Number | 147526-32-7 |
Solubility (25°C) | DMSO 49 mg/mL |
Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
[2] Paul Chan, et al. An evaluation of pitavastatin for the treatment of hypercholesterolemia
Related Autophagy Products |
---|
Sofalcone
Sofalcone is a gastric antiulcer agent, it is known to induce the expression of Heme oxygenase-1 (HO-1) in gastric epithelium. |
P62-mediated mitophagy inducer
P62-mediated mitophagy inducer (PMI) is a P62-mediated mitophagy activator. P62-mediated mitophagy inducer activates mitochondrial autophagy without recruitment of Parkin or collapse of the mitochondrial membrane potential and remains active in cells lacking a fully functional PINK1/Parkin pathway. |
FDW028
FDW028 is a potent and highly selective FUT8 inhibitor. FDW028 exhibits potent anti-tumor activity by defucosylation and impelling lysosomal degradation of B7-H3 through the CMA pathway. |
Calmodulin-Dependent Protein Kinase II (290-309)
Calmodulin-Dependent Protein Kinase II (290-309) is a potent CaMK antagonist with an IC50 of 52 nM for inhibition of Ca2+/calmodulin-dependent protein kinase II. |
Microcolin H
Microcolin H is a marine lipopeptide and phosphatidylinositol transfer protein ligand that targets PITPα/β. |
Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2023 AbMole BioScience. All Rights Reserved.