About 10 results found for searched term "Z-Thr-OMe" (0.128 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M51994 | Z-Thr-OMe | Amino Acid Derivatives |
| Z-Thr-OMe is a threonine derivative. | ||
| M2152 | Carfilzomib | Proteasome |
| PR-171 | ||
| Carfilzomib (PR-171) is an irreversible proteasome inhibitor with an IC50 of <5 nM. Carfilzomib irreverently selectively binds to the active site containing n-terminal threonine of the 20S proteasome and proteolytic core particles of the 26S proteasome.*The compound is unstable in solutions, freshly prepared is recommended. | ||
| M2303 | Capivasertib (AZD5363) | Akt |
| AZD-5363 | ||
| Capivasertib (AZD5363) is a potentially first-in-class, orally effective pan-AKT inhibitor with strong inhibition against all three AKT isomers (AKT1/2/3) at an IC50 of 3 nM/8 nM/8 nM. It also showed similar inhibitory effect on P70S6K/PKA and low inhibitory activity on ROCK1/2. | ||
| M2995 | Salinosporamide A | Proteasome |
| (-)-Salinosporamide A; ML 858; NPI 0052; Marizomib | ||
| Salinosporamide A (NPI-0052, Marizomib) is a novel marine derived proteasome inhibitor which inhibits CT-L, C-L, and T-L proteasome activities in human erythrocyte-derived 20S proteasomes with EC50 of 3.5 nM, 430 nM, 28 nM. | ||
| M4896 | Nicotinamide | Sirtuin |
| Vitamin B3; Nicotinic acid amide; Niacinamide | ||
| Nicotinamide is an active component of coenzymes NAD and NADP, and also act as an inhibitor of sirtuins. Nicotinamide plays essential roles in cell physiology through facilitating NAD+ redox homeostasis and providing NAD+ as a substrate to a class of enzymes that catalyze non-redox reactions. | ||
| M10127 | Azathramycin | Antibiotic |
| Azaerythromycin A; Desmethyl Azithromycin | ||
| Azathramycin is an antibiotic, binding to the 50S subunit of the bacterial ribosome, and thus inhibits translation of mRNA. | ||
| M11170 | NSC745885 | Apoptosis |
| NSC745885 is a potent anti-tumor reagent that is selectively toxic to a variety of cancer cell lines but not to normal cells. NSC745885 is a potent downregulator of EZH2 through the proteasome degradation pathway. NSC745885 offers the possibility of research on advanced bladder cancer and oral squamous cell carcinoma. | ||
| M24709 | Prezalumab | Others |
| AMG 557 | ||
| Prezalumab (AMG 557) is a humanized IgG2 monoclonal antibody targets ICOSL and BAFF. Prezalumab demonstrates beneficial activities on the arthritis of systemic lupus erythematosus. Prezalumab can be used for the research of sjogren's syndrome cutaneous lupus erythematosus, psoriasis and systemic lupus erythematosus (SLE). | ||
| M29455 | DDO-7263 | Keap1-Nrf2 |
| DDO-7263, a 1,2,4-Oxadiazole derivative, is a potent Nrf2-ARE activator. DDO-7263 upregulates Nrf2 through binding to Rpn6 to block the assembly of 26S proteasome and the subsequent degradation of ubiquitinated Nrf2. DDO-7263 induces Nrf2 translocation into the nucleus. DDO-7263 inhibits of NLRP3 inflammasome activation. DDO-7263 exerts anti-inflammatory activity and has the potential for neurodegenerative diseases research, such as Parkinson's disease (PD). | ||
| M30832 | ONO-2952 | Adrenergic Receptor |
| ONO-2952 is a potent, selective and orally active translocator protein 18 kDa (TSPO) antagonist with Ki of 0.33-9.30 nM for rat and human TSPO. ONO-2952 is more selective for TSPO than other receptors, transporters, ion channels and enzymes. ONO-2952 exerts its anti-stress effects through inhibition of excessive activation of noradrenergic system in the brain without the amnesic effect. ONO-2952 has the potential for irritable bowel syndrome treatment. | ||
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