About 2 results found for searched term "X-376" (0.099 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M1743 | X-376 | ALK |
| X-376 is a potent and highly specific ALK small molecule tyrosine kinase inhibitor with IC50 of 0.61 nM. | ||
| M27770 | Nemorubicin | DNA/RNA Synthesis |
| Methoxymorpholinyl doxorubicin; FCE 23762; PNU 152243 | ||
| Nemorubicin (Methoxymorpholinyl doxorubicin) is a Doxorubicin derivative with potent antitumor activity. Nemorubicin is highly cytotoxic to a variety of tumor cell lines presenting a multidrug-resistant phenotype. Nemorubicin not only intercalate into the duplex DNA, but also result in significant ligands for G-quadruplex DNA segments, stabilizing their structure. Nemorubicin requirs an intact nucleotide excision repair (NER) system to exert its activity. | ||
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