About 1 result found for searched term "Vipoglanstat" (0.126 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M58604 | Vipoglanstat | PGE synthase |
| BI 1029539; GS-248; OX-MPI | ||
| Vipoglanstat (BI 1029539) is an inhibitor of microsomal prostaglandin E synthase-1 (mPGES-1; IC50 = ≤0.5 nM in isolated human whole blood). Vipoglanstat reduces LPS-induced increases in the influx of neutrophils and levels of cytokines in bronchoalveolar lavage fluid (BALF), as well as the expression of PTGES, the gene encoding mPGES-1, Cox2, and Icam1 in the lung parenchyma, in a human PTGES knock-in mouse model of acute lung injury when administered at a dose of 30 mg/kg. | ||
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