About 2 results found for searched term "Vimirogant" (0.129 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M9265 | Vimirogant | ROR |
| AGN-242428; VTP-43742; RORγ-IN-1 | ||
| Vimirogant (also known as AGN-242428 and VTP-43742) is a potent, selective and orally active RORγt inhibitor. | ||
| M31061 | Vimirogant hydrochloride | ROR |
| VTP-43742 hydrochloride | ||
| Vimirogant (VTP-43742) hydrochloride is a potent, selective, and orally active RORγt inhibitor (Ki=3.5 nM; IC50=17 nM). Vimirogant hydrochloride exhibits >1000-fold selectivity versus the RORα and RORβ isotypes. Vimirogant hydrochloride inhibits Th17 differentiation and IL-17A secretion from mouse splenocytes (IC50=57 nM) without affecting Th1, Th2, or Treg cell differentiation. | ||
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