TrkB-IN-1 - Search Results | AbMole BioScience

About 3 results found for searched term "TrkB-IN-1" (0.126 seconds)

Cat.No.	Name	Target
M42718	TrkB-IN-1	Trk
	TrkB-IN-1 is a potent and orally active TrkB agonist and has favorable PK properties.
M2790	K252a	PKC
	SF 2370; Antibiotic K-252a; Antibiotic SF 2370
	K252a is an inhibitor of the BDNF receptor TrkB. K-252a inhibits protein kinase with IC50 values of 470 nM, 140 nM, 270 nM, and 1.7 nM for PKC, PKA, Ca2+/calmodulin-dependent kinase type II, and phosphorylase kinase, respectively. K-252a is a potent inhibitor (IC50 of 3 nM) of the tyrosine protein kinase (TRK) activity of the NGF receptor gp140trk, the product of the trk protooncogene.
M9626	Sitravatinib	VEGFR/PDGFR
	MGCD516; MG516
	Sitravatinib (MGCD516) is an orally active receptor tyrosine kinase (RTK) inhibitor. Inhibition of Axl, MER, VEGFR3, VEGFR2, VEGFR1, KIT, FLT3, DDR2, DDR1, TRKA, and TRKB at 1.5 nM, 2 nM, 2 nM, 5 nM, 6 nM, 6 nM, 8 nM, 0.5 nM, respectively. 29 nM, 5 nM and 9 nM. Sitravatinib alone has a potent antitumor effect and enhances pD-1 blockade activity by promoting the antitumor immune microenvironment.