About 1 result found for searched term "Teprotumumab" (0.135 seconds)
Cat.No. | Name | Target |
---|---|---|
M24540 | Teprotumumab | IGF-1R |
RV001; R1507 | ||
Teprotumumab (RV001, R1507) is a first-in-class IGF-1 receptor (IGF-1R) blocking human monoclonal antibody. Teprotumumab binds to the ligand binding extracellular α-subunit domain of IGF-1R. Teprotumumab inhibits TSH and IGF-1 action in fibrocytes. Teprotumumab attenuates TSH-dependent IL-6 and IL-8 expression and Akt phosphorylation. Teprotumumab can be used for thyroid-associated ophthalmopathy research. |
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