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Teprotumumab (RV001, R1507) is a first-in-class IGF-1 receptor (IGF-1R) blocking human monoclonal antibody. Teprotumumab binds to the ligand binding extracellular α-subunit domain of IGF-1R. Teprotumumab inhibits TSH and IGF-1 action in fibrocytes. Teprotumumab attenuates TSH-dependent IL-6 and IL-8 expression and Akt phosphorylation. Teprotumumab can be used for thyroid-associated ophthalmopathy research.
| CAS Number | 1036734-93-6 |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
[1] Tina Nie, et al. Drugs. Teprotumumab: A Review in Thyroid Eye Disease
[3] No authors listed. Teprotumumab
[5] Terry J Smith, et al. N Engl J Med. Teprotumumab for Thyroid-Associated Ophthalmopathy
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