About 5 results found for searched term "THZ2" (0.13 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M8995 | THZ2 | CDK |
| THZ2 (an analog of THZ1) is a potent and selective CDK7 inhibitor which overcomes the instability of THZ1 in vivo (IC50s: CDK7=13.9 nM; TNBC cells=10 nM). | ||
| M21521 | THZ-P1-2 | PI5P4K |
| THZ-P1-2 is a first-in-class, selective PI5P4K inhibitor with an IC50 of 190 nM for Pi5P4α. | ||
| M9779 | THZ531 | CDK |
| THZ-531 | ||
| THZ531 is a covalent CDK12 and CDK13 inhibitor with IC50 values of 158 nM and 69 nM, respectively. | ||
| M10913 | THZ1-R | CDK |
| THZ1-R is a non-cysteine-reactive analogue of THZ1 with reduced activity against CDK7 inhibition. THZ1-R in combination with CDK7 Kd 142 nM. | ||
| M13617 | THZ1 Hydrochloride | CDK |
| THZ1 Hydrochloride is a selective and potent covalent CDK7 inhibitor with an IC50 of 3.2 nM. THZ1 Hydrochloride also inhibits the closely related kinases CDK12 and CDK13 and downregulates MYC expression. | ||
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