About 30 results found for searched term "TC-F 2" (0.094 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M7369 | TC-F 2 | Others |
| TC-F 2 is a potent, reversible and selective FAAH inhibitor. | ||
| M1771 | Ataluren | CFTR |
| PTC124 | ||
| Ataluren (PTC124) is a novel, orally available small molecular CFTR-G542X nonsense allele inhibitor. | ||
| M2087 | HC-030031 | TRP Channel |
| HC-030031 is a selective TRPA1 blocker, antagonizing TRPA1-mediated calcium influx induced by AITC and formalin (IC50 = 6.2 and 5.3 μM, respectively). | ||
| M2703 | FLI-06 | Notch |
| FLI-06 is a novel inhibitor of Notch signaling with EC50 of 2.3 μM. | ||
| M2828 | LY900009 | Notch |
| LY900009 is a potent, first-in-class Notch inhibitor with IC50 of 0.27 nM. | ||
| M3052 | TCID | Deubiquitinase |
| 4,5,6,7-Tetrachloroindan-1,3-dione | ||
| TCID is a DUB inhibitor for ubiquitin C-terminal hydrolase L3 with IC50 of 0.6 μM, 125-fold selective to L1. | ||
| M3053 | TCS 359 | FLT3 |
| TCS 359 is a potent FLT3 inhibitor with IC50 of 42 nM. | ||
| M3189 | TCN-201 | GluR |
| TCN201 | ||
| TCN 201 is a NMDA receptor antagonist for NR1/NR2A and NR1/NR2B with pIC50 of 6.8 and 4.3, respectively. | ||
| M3619 | Begacestat | Gamma-secretase/Beta-secretase |
| GSI-953 | ||
| Begacestat selectively inhibits cleavage of amyloid precursor protein (APP) over Notch. Lowers levels of Aβ42 and Aβ40 (EC50 values are 12.4 and 14.8 nM respectively in cells expressing human recombinant APP). | ||
| M3645 | MG149 | Histone Acetyltransferase |
| MG149 is a selective and potent Tip60 inhibitor with IC50 of 74 uM, similar potentcy for MOF (IC50= 47 uM); little potent for PCAF and p300 (IC50 >200 uM). | ||
| M3745 | TCS PIM-1 1 | Pim |
| SC 204330 | ||
| TCS PIM-1 1 is a potent and selective ATP-competitive Pim-1 kianse inhibitor with IC50 of 50 nM, displays good selectivity over Pim-2 and MEK1/MEK2(IC50s > 20,000 nM). | ||
| M3760 | TCS-1102 | OX Receptor |
| TCS 1102 is a potent, dual orexin receptor antagonist (Ki values are 0.2 and 3 nM for OX2 and OX1 receptors respectively). | ||
| M1261 | NFAT Inhibitor-1 (VIVIT peptide) | NFAT |
| VIVIT peptide; NFAT Inhibitor; ABM-7733 | ||
| NFAT Inhibitor-1 (VIVIT peptide) is a cell-permeable peptide inhibitor of nuclear factor of activated Tcells (NFAT), it is superior at inhibiting calcineurin-mediated dephosphorylation of NFAT1, NFAT2, and NFAT4 in cell extracts. | ||
| M4866 | LF3 | Wnt/beta-catenin |
| LF3 is a specific inhibitor of canonical Wnt signaling by disrupting the interaction between β-catenin and TCF4 with an IC50 less than 2 μM. | ||
| M5207 | Bempedoic acid (ETC-1002) | AMPK |
| ESP-55016; Bempedoic acid | ||
| Bempedoic acid (ETC-1002) is a novel, first-in-class, orally available ATP-citrate lyase (ACL) inhibitor, Bempedoic acid (ETC-1002) can activate AMPK. | ||
| M6313 | PTC-028 | Apoptosis |
| PTC-028 is an orally bioavailable inhibitor of stem cell factor BMI-1, it downregulates BMI-1, inducing caspase-mediated apoptosis. PTC-028 is an orally bioavailable compound that decreases BMI-1 levels by posttranslational modification. | ||
| M7364 | TCB2 | 5-HT Receptor |
| TCB-2 | ||
| TCB-2 is a potent, high affinity 5-HT2A agonist. | ||
| M7370 | TC-FPR 43 | FPR |
| TC-FPR 43 is a potent FPR2 agonist. | ||
| M7372 | TC-G 1003 | Somatostatin Receptor |
| TCG1003 | ||
| TC-G 1003 is a high affinity somatostatin sst2 receptor agonist. | ||
| M7374 | TC-H 106 | HDAC |
| Pimelic Diphenylamide 106; RGFA-8; Histone Deacetylase Inhibitor VII | ||
| TC-H 106 is a class I histone deacetylase inhibitor, with IC50 values of 150 nM , 760 nM and 370 nM for HDAC 1, 2, and 3, respectively. | ||
| M7392 | TC-S 7009 | Others |
| TC-S 7009 is a high affinity and selective HIF-2α inhibitor. | ||
| M7396 | TCS-OX2-29 | OX Receptor |
| TCS-OX2-29 is a potent, high affinities and selective orexin-2 receptor (OX2R) antagonist with an IC50 value of 40 nM and a pKI value of 7.5. TCS-OX2-29 displays ~250-fold selectivity for OX2 over OX1. | ||
| M7667 | BMS-906024 | Notch |
| Osugacestat | ||
| BMS-906024 is a γ-secretase inhibitor and pan-Notch inhibitor with IC50 values of 1.6 nM, 0.7 nM, 3.4 nM, and 2.9 nM for Notch1, 2, 3, and 4 receptors, respectively. BMS-906024 has antineoplastic activity. | ||
| M8679 | IMR-1 | Notch |
| IMR-1 is a first-in-class, cell-permeable inhibitor of the Notch transcription activation complex, with an IC50 of 26 μM. IMR-1 prevents Maml1 from recruiting to the Notch ternary complex (NTC) in chromatin, inhibits transcription of Notch target genes, and has antitumor activity. | ||
| M8934 | ETC-159 | Wnt/beta-catenin |
| ETC-1922159 | ||
| ETC-159 is a potent, selective and orally available PORCN inhibitor, which inhibits β-catenin reporter activity with an IC50 of 2.9 nM. | ||
| M9298 | AX-024 hydrochloride | Immunology/Inflammation |
| AX-024 HCl | ||
| Ax-024 Hydrochloride is orally available, the first tCR-NCK interaction inhibitor that selectively inhibits TCR-induced T cell activation with an IC50 value of 1 nM. Ax-024 Hydrochloride regulates cellular signaling by targeting the SH3 domain. Ax-024 Hydrochloride has the characteristics of low toxicity, high efficiency and high selectivity. | ||
| M9509 | NS-3-008 hydrochloride | Immunology/Inflammation |
| NS-3-008 hcl | ||
| NS-3-008 hydrochloride is an orally active transcriptional inhibitor of G0/G1 switch 2 (G0s2) with an IC50 of 2.25 μM. | ||
| M11128 | Segetalin C | Antibiotic |
| Cyclopeptide (compound VIII) has good activity against pathogenic fungi Candida albicans and dermatophytes, in addition to high cytotoxicityagainst Dalton's lymphoma ascites (DLA) and Ehrlich's ascites carcinoma (EAC) cell lines with CTC50 values of 3.35 and 5.72 micromol/L. | ||
| M11402 | TCH-165 | Proteasome |
| Tch-165 is a small molecule modulator of proteasome assembly that increases 20S levels and promotes 20S-mediated protein degradation. | ||
| M14493 | MSI-1436 lactate | Phosphatase |
| Trodusquemine lactate; Aminosterol-1436 lactate | ||
| MSI-1436 lactate is a selective, non-competitive inhibitor of the enzyme protein-tyrosine phosphatase 1B (PTP1B), with an IC50 of 1 μM, 200-fold preference over TCPTP (IC50 of 224 μM). | ||
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