About 32 results found for searched term "TAI-1" (0.08 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M5293 | Protease Inhibitor Cocktail (EDTA-Free, 100X in DMSO) | Inhibitor Cocktails |
| Protease inhibitor cocktails are used in mammalian cell lysates or tissue extracts to increase protein stability. | ||
| M13406 | Deacetylase Inhibitor Cocktail (100X) | Inhibitor Cocktails |
| AbMole Deacetylase Inhibitor Cocktail is a synergistic combination of chemicals designed to preserve the acetylation state of proteins. AbMole Deacetylase Inhibitor Cocktail (100X) is provided as 1 mL vial. Each vial contains 1 mL 70% DMSO with the following components: Trichostatin A (40 μM), EX-527 (1 mM), Nicotinamide (400 mM), and Sodium Butyrate (200 mM). | ||
| M20601 | TAI-1 | Microtubule |
| TAI-1 is a first-in-class, potent, specific, orally active Hec1 inhibitor that disrupts the Hec1-Nek2 protein interaction. | ||
| M1970 | Paclitaxel | Microtubule |
| Taxol; NSC 125973 | ||
| Paclitaxel is a diterpenoid derived from the bark of the plant Picea abies, and is also a microtubule polymer stabilizer, which promotes polymerization of microtubule proteins to inhibit depolymerization, maintains the stability of microtubule proteins, and inhibits cellular mitosis, and acts on human endothelial cells with an IC50 of 0.1 pM. | ||
| M22515 | Avidin (from egg white) | Western Blot |
| Immunopure Avidin | ||
| Avidin is homotetrameric protein (68kDa) that is obtained from egg whites. Avidin forms an extremely strong complex with d-biotin (Kd ~ 10-15). This activity has made both avidin and biotin extremely useful labels in immunochemical methods of detection and quantitation. | ||
| M25536 | Recombinant Human CXCL13/BCA-1 (E. coli) | Recombinant Proteins |
| CXC chemokine BLC; Small-inducible cytokine B13 | ||
| CXCL13, also known as B-lymphocyte chemoattractant (BLC), is a CXC chemokine that is constitutively expressed in secondary lymphoid organs. Recombinant human CXCL13 is a single non-glycosylated polypeptide chain containing 87 amino acids and mature human BCA-1 shares 64 % amino acid sequence similarity with the murine protein and 23–34 % amino acid sequence identity with other known CXC chemokines. Determined by a chemotaxis bioassay using human B cells, the biological activity is in a concentration range of 1.0-10 ng/ml. | ||
| M25394 | BPTF-IN-1 | Epigenetic Reader Domain |
| compound AU1 | ||
| BPTF-IN-1 (compound AU1) is a selective bromodomain and PHD finger containing transcription factor (BPTF) bromodomain inhibitor with a Kd of 2.8 μM. BPTF-IN-1 shows to be selective for BPTF over BRD4 bromodomain. | ||
| M3757 | Obatoclax Mesylate | Bcl-2 |
| GX15-070, Obatoclax | ||
| Obatoclax is an antagonist of Bcl-2 family members containing four Bcl-2 homology domains, including Bcl-2, Bcl-W, Bcl-XL, and Mcl-1 (KD = ~500 nM). | ||
| M4560 | Paeonolide | Others |
| Paeonolide is a plant glycoside containing a non-reducing terminal α -1-arabopyranoside, which is present in the roots of a wide range of plants of the Genus Paeonia. | ||
| M4637 | Jaceosidin | Bcl-2 |
| Jaceosidin is a flavonoid obtained from Artemisia vestita, which can activate Bax, down-regulate the expression of McL-1 and C-flip, and induce apoptosis of cancer cells. Jaceosidin has anti-cancer and anti-inflammatory effects, which can reduce the level of inflammatory factors, activate NF-κB, and inhibit the expression of COX-2. | ||
| M4686 | Eriodictyol | Immunology/Inflammation |
| Eriodictyol is a flavonoid obtained from Chinese herbs, which has antioxidant and anti-inflammatory properties. Eriodictyol can induce Nrf2 signaling pathway. Eriodictyol is also an influenza dependent RNA polymerase inhibitor with an IC50 of 18 nM. | ||
| M4746 | Isovitexin | JNK |
| Isovitexin, a flavonoid obtained from Asian rice seeds, has antioxidant and anti-inflammatory activities. Isovitexin acts like an inhibitor of JNK1/2 and inhibits NF-κB activation. | ||
| M4833 | Eliprodil | GluR |
| SL-820715 | ||
| Eliprodil is a non-competitive NR2B-NMDA receptor antagonist(IC50=1 uM), less potent for NR2A- and NR2C-containing receptors(IC50> 100 uM). | ||
| M5115 | Fluorescein diacetate (FDA) | Fluorescent Dye |
| 3,6-Diacetoxyfluoran; Di-O-acetylfluorescein | ||
| Fluorescein diacetate (FDA), a fluorescent probe used for vital staining, is a fluorescently activated by esterolytic activity of human Pi-class glutathione S-transferase (hGSTP1) selectively among various cytosolic GSTs. | ||
| M5269 | GSK180736A | ROCK |
| GSK180736 | ||
| GSK180736A, developed as a Rho-associated, coiled-coil-containing protein kinase inhibitor, binds to GRK2(G protein-coupled receptor kinase 2) with logIC50 pf -6.6 (logIC50 -4.0 for GRK5 and >-3 for GRK1); ≥400-fold selective for GRK2 over both GRK1 and GRK5. | ||
| M6046 | Uridine | DNA/RNA Synthesis |
| NSC 20256 | ||
| Uridine is a nucleoside, contains a uracil attached to a ribose ring via a β-N1-glycosidic bond. | ||
| M6132 | ECBN HCL | Others |
| ECBN obtained by the fermentation of Aspergillus nidulans and Aspergillus rugulosus, is known as one of the natural cyclic hexapeptides that have a linoleoyl side chain, which inhibits a crucial enzyme in fungal cell wall biosynthesis, β-(1,3)-d-glucan synthase. | ||
| M6159 | GSK-2018682 | LPL Receptor |
| This compound belongs to the class of organic compounds known as n-alkylindoles. These are compounds containing an indole moiety that carries an alkyl chain at the 1-position. | ||
| M6896 | Latrunculin A | Actin-Related Protein |
| LAT-A | ||
| Latrunculin A (Latrunculia magnifica) is A toxin obtained from the Red Sea sponge Latrunculia magnifica that binds to actin monocytes and inhibits actin aggregation, inhibiting atP-actin, ADP-pi-actin, Kd values of ADP-actin and G-actin were 0.1, 0.4, 4.7 μM and 0.19 μM, respectively. | ||
| M7658 | BTA-1 | Others |
| BTA-1 is a probe for β-amyloid aggregates; fluorescent thioflavin-T derivative; exhibits high affinity for amyloid deposits; displays 50-fold higher affinity than thioflavin-T; selectively stains cerebral plaques and cerebrovascular amyloid deposits in the brains of PS1/APP transgenic mice, as well as Aβ fibrils in postmortem brain tissue obtained from AD patients; crosses the blood brain barrier. | ||
| M7676 | BMS-763534 | Others |
| BMS-763534 is a pyrazinone-containing antagonist that targets corticotropin-releasing factor/hormone (CRF or CRH) receptor 1 (CRF1, CRF-R1, CRFR-1, CRH-R1, CRHR-1) with high affinity (IC50 = 0. | ||
| M7677 | BMS-665053 | Others |
| BMS-665053 is a pyrazinone-containing antagonist that targets corticotropin-releasing factor/hormone (CRF or CRH) receptor 1 (CRF1, CRF-R1, CRFR-1, CRH-R1, CRHR-1) with high affinity (IC50 | ||
| M7678 | BMS-764459 | Others |
| BMS-764459 is a pyrazinone-containing antagonist that targets corticotropin-releasing factor/hormone (CRF or CRH) receptor 1 (CRF1, CRF-R1, CRFR-1, CRH-R1, CRHR-1) with high affinity (IC50 = 0. | ||
| M8199 | SR11237 | RAR/RXR |
| SR11237 is a retinoid X receptor (RXR) selective agonist without any RAR activity that leads to the formation of RXR/RXR homodimers and activation of reporter genes containing RXR response elements. In addition, SR11237 significantly promotes reprogramming. | ||
| M8467 | OF-1 | Others |
| OF-1 is a chemical probe for the bromodomains of the BRPF (BRomodomain and PHD Finger containing) family of scaffolding proteins (BRPF1, BRPF2, BRPF3) that assemble histone acetyltransferase (HAT) complexes of the MYST family members MOZ and MORF. | ||
| M9708 | Chymotrypsin | Enzymes & Coenzymes |
| α-Chymotrypsin | ||
| α-Chymotrypsin is a serine peptidase and has 241 amino acid residues contained in three polypeptide chains (A chain-13 residues, B chain-131 residues, and C chain-97 residues) linked by disulfide bridges. | ||
| M10286 | Recombinant Murine Midkine (E. coli) | Recombinant Proteins |
| rmMK; rm-midkine | ||
| Midkine is a heparin-binding growth factor, which contains 121 amino acid residues with 5 disulfide bonds. | ||
| M10546 | Indophagolin | Autophagy |
| Indophagolin is a potent, indoline-containing autophagy inhibitor (IC50=140 nM). Indophagolin antagonizes the purinergic receptor P2X4 as well as P2X1 and P2X3 with IC50s of 2.71, 2.40 and 3.49 μM, respectively. | ||
| M10805 | Cercosporin | PKC |
| cgp049090 | ||
| Cercosporin is produced by the plant pathogenSporakikuchii and elsinochromes, pigments of the elsinoe family of fungi. Cercosporin is an effective photosensitizer with a short activation wavelength that is primarily suitable for surface PDT photodynamic studies (especially for the avoidance of perforation studies). Cercosporin contains the perylenequinone structural features necessary to PKC activity with an IC50 of 0.6-1.3 μM. | ||
| M10943 | Atabecestat | BACE |
| JNJ-54861911 | ||
| Atabecestat (JNJ-54861911) is a potent brain-osmotic and has oral activity β-position amyloid precursor protein lyase 1 (BACE1 inhibitors that strongly reduce the expression of Aβ protein in cerebrospinal fluid. Atabecestat (JNJ-54861911) is tolerant and has sustained pharmacokinetic (PK) and pharmacodynamic (PD) profiles. Atabecestat (JNJ-54861911) has the potential to be used in the study of Alzheimer's disease. | ||
| M11427 | RM-018 | Ras |
| INDEX NAME NOT YET ASSIGNED | ||
| RM-018 is an inhibitor of the active state of KRASG12C. Rm-018 retains the ability to bind and inhibit KRASG12C/Y96D. Rm-018 combines with GTP-bound to activate the [" RAS(ON) "] state of KRASG12C. | ||
| M13548 | SM-164 Hydrochloride | IAP |
| SM-164 Hydrochloride is a cell-permeable Smac mimetic compound. SM-164 binds to XIAP protein containing both the BIR2 and BIR3 domains with an IC50 value of 1.39 nM and functions as an extremely potent antagonist of XIAP. | ||
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