About 6 results found for searched term "Syk-IN-7" (0.204 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M43533 | Syk-IN-7 | Syk |
| Syk-IN-7 is an inhibitor of spleen tyrosine kinase (SYK). | ||
| M2729 | GS-9973 | Syk |
| Entospletinib | ||
| GS-9973 is an orally bioavailable, selective Syk inhibitor with IC50 of 7.7 nM. | ||
| M5247 | BAY 61-3606 dihydrochloride | Syk |
| BAY-61-3606 is a potent and selective inhibitor of Syk kinase (Ki = 7.5 nM). | ||
| M21588 | GSK2646264 | Syk |
| GSK2646264 is a potent and selective splenic tyrosine kinase (Syk) inhibitor with a pIC50 value of 7.1. GSK2646264 also inhibited other kinases, with pIC50 values of 5.4, 5.4, 5.3, 5, 4.5, <4.6 and <4.3 for LCK, LRRK2, GSK3β, JAK2, VEGFR2, Aurora B and Aurora A, respectively. GSK2646264 penetrates into the epidermis and dermis of the skin. | ||
| M28411 | TAS05567 | Syk |
| TAS05567 is a potent, highly selective, ATP-competitive and orally active Syk inhibitor with an IC50 of 0.37 nM. In a panel of 192 kinases, TAS05567 only shows >70% inhibition of Syk and 4 other kinases (FLT3, JAK2, KDR and RET with IC50s of 10 nM, 4.8 nM, 600 nM and 29 nM, respectively). TAS05567 can be used for humoral immune-mediated inflammatory conditions such as autoimmune and allergic diseases. | ||
| M30952 | Lck inhibitor 2 | Src-bcr-Abl |
| Lck inhibitor 2 is a bis-anilinopyrimidine inhibitor of tyrosine kinases including LCK, BTK, LYN, SYK, and TXK. The IC50 values are 13nM, 9nM, 3nM, 26nM and 2nM for Lck, Btk, Lyn, Btk and Txk respectively IC50 Value: 13 nM(Lck) [1] Target: Src family kinase Lck inhibitor 2(Compound 9) inhibited 48 kinases with %control < 1 (33 of them tyrosine kinases, almost half of the 71 tyrosine kinases in the panel). A further 27 kinases were bound with %control < 10. Kd values for 16 kinases were determined and found to be below 100 nM. These included TXK (10 nM). | ||
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