About 7 results found for searched term "STAT3-IN-13" (0.122 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M49681 | STAT3-IN-13 | STAT |
| STAT3-IN-13 is a potent STAT3 inhibitor. | ||
| M3001 | SC144 | IL Receptor/Related |
| SC144 is the first oral active GP130 (IL6-beta) inhibitor. SC144 binds gp130, induces gp130 phosphorylation (S782) and deglycosylation, eliminates Stat3 phosphorylation and nuclear translocation, and further inhibits downstream target gene expression. SC144 inhibited signal transduction induced by GP130 ligand. SC144 induces apoptosis of human ovarian cancer cells. | ||
| M7273 | SC 144 hydrochloride | IL Receptor/Related |
| SC144 hydrochloride is the first oral active GP130 (IL6-beta) inhibitor. SC144 hydrochloride binds gp130, inducing phosphorylation (S782) and deglycosylation of GP130, eliminating Stat3 phosphorylation and nuclear translocation, and further inhibiting the expression of downstream target genes. SC144 hydrochloride inhibited signal transduction induced by GP130 ligand. SC144 hydrochloride induces apoptosis of human ovarian cancer cells. | ||
| M7647 | Bryostatin 1 | PKC |
| Bryostatin 1 is a natural macrolide isolated from the moss bug Bugula neritina and a potent PKC modulator of central nervous system (CNS) permeability.Bryostatin 1 binds to the isolated Munc13-1 C1 domain and the full-length Munc13-1 protein with a Ki value of 8.07 and 0.45 nM, respectively, and has anticancer, anti-inflammatory and neuroprotective activities. Bryostatin 1 binds to the isolated C1 domain of Munc13-1 and the full-length Munc13-1 protein with Ki values of 8.07 nM and 0.45 nM, respectively, and exhibits anticancer, anti-inflammatory, and neuroprotective activities. | ||
| M28939 | AC-4-130 | STAT |
| AC-4-130 is a potent STAT5 SH2 domain inhibitor. AC-4-130 directly binds to STAT5 and disrupts STAT5 activation, dimerization, nuclear translocation, and STAT5-dependent gene transcription. AC-4-130 induces cell cycle arrest and apoptosis in FLT3-ITD-driven leukemic cells. AC-4-130 has anti-cancer activity and can efficiently block pathological levels of STAT5 activity in acute myeloid leukemia (AML). | ||
| M39011 | W1131 | STAT |
| W1131 is a potent STAT3 inhibitor, triggering ferroptosis. W1131 effectively alleviates chemical resistance of cancer cells to 5-FU. W1131 regulates cell cycle, DNA damage response, and oxidative phosphorylation, including IL6-JAK-STAT3 pathway and ferroptosis pathway. | ||
| M49670 | MC0704 | STAT |
| MC0704 is a STAT3 inhibitor with an IC50 value of 2.13 μM. | ||
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