About 1 result found for searched term "SRI-41315" (0.133 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M54648 | SRI-41315 | CFTR |
| SRI-41315 inhibits PTCs (premature termination codons) associated with cystic fibrosis in permanent and primary human bronchial epithelial cells by inducing a prolonged stoppage of the termination codon, restoring the expression and function of cystic fibrosis transmembrane conductance regulator (CFTR). In addition, SRI-41315 enhances aminoglycoside-mediated passaging, leading to a synergistic increase in CFTR activity. | ||
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