About 10 results found for searched term "SP-420" (0.123 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M3688 | SP-420 | Others |
| SP420 | ||
| SP-420 is an orally active small molecule that selectively binds iron and removes it from the body. | ||
| M30224 | SP4206 | IL Receptor/Related |
| SP4206 is an IL-2/IL-2Rα interaction inhibitor. SP4206 binds with high affinity (Kd=70 nM) to IL-2 and blocks binding to its natural receptor IL-2Rα (Kd=10 nM). | ||
| M51646 | Phosphorylase Kinase β-Subunit Fragment (420-436) | Others |
| Phosphorylase Kinase β-Subunit Fragment (420-436) is the β-Subunit fragment (peptide 430-436) of phosphorylase kinase. | ||
| M2852 | Milnacipran hydrochloride | 5-HT Receptor |
| Milnacipran inhibits both norepinephrine transporter (NET) and norepinephrine transporter (SERT) with IC50 of 77 nM and 420 nM, respectively. | ||
| M3028 | Spironolactone | Mineralocorticoid Receptor |
| SC9420; Abbolactone | ||
| Spironolactone (SC9420) is an oral active aldosterone mineralocorticoid receptor antagonist with an IC50 value of 24 nM. Spironolactone is also an androgen receptor antagonist with an IC50 of 77 nM. Spironolactone promotes podocyte autophagy. | ||
| M8671 | UCPH-102 | Others |
| UCPH-102 is a selective inhibitor of the Excitatory Amino Acid Transporter subtype-1 (EAAT1, GLAST) with an IC50 value of 420 nM for EAAT1 and >300 μM for EAAT2-5. | ||
| M10619 | Rhodiosin | AChR/AChE |
| Rhodiosin, isolated from the root of Rhodiola crenulata, is a specific non-competitive cytochrome P450 2D6 inhibitor with an IC50 of 0.420 μM and a Ki of 0.535 μM. Rhodiosin exhibits potent, dose-dependent inhibitory effects on acetylcholinesterase (AChE) with IC50 ranged from 57.50 to 2.43 μg/mL. | ||
| M21366 | AGN194204 | RAR/RXR |
| IRX4204; NRX194204; VTP 194204 | ||
| AGN194204 (IRX4204) is inactive against RAR and is an orally active and selective RXR agonist with Kd values of 0.4 nM, 3.6 nM and 3.8 nM for RXRα, RXRβ and RXRγ, respectively, and EC50s of 0.2 nM, 0.8 nM and 0.08 nM. AGN194204 has anti-inflammatory and anti-cancer effects. | ||
| M25041 | Pavurutamab | Others |
| AMG-701 | ||
| Pavurutamab (AMG-701) is a bispecific T cell engager molecule that anti-CD3 and anti-B cell maturation antigens (BCMA). Pavurutamab has an extended half-life based on AMG-420 . The Fc of Pavurutamab is coupled to molecules to improve pharmacokinetic parameters. Pavurutamab has potential applications in immune regulation and multiple myeloma (MM). | ||
| M28033 | ST4206 | Adenosine Receptor |
| ST4206 is a potent and orally active adenosine A2A receptor antagonist, with Kis of 12 nM and 197 nM for adenosine A2A receptor and adenosine A1 receptor, respectively. ST4206 has the potential for Parkinson׳s disease research. | ||
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