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SP4206 

Cat. No. M30224

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SP4206  Structure

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Quality Control & Documentation
Biological Activity

SP4206 is an IL-2/IL-2Rα interaction inhibitor. SP4206 binds with high affinity (Kd=70 nM) to IL-2 and blocks binding to its natural receptor IL-2Rα (Kd=10 nM).

Chemical Information
Molecular Weight 662.56
Formula C30H37Cl2N7O6
CAS Number 515846-21-6
Form Solid
Solubility (25°C) DMSO 100 mg/mL (ultrasonic)
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Yibing Shan, et al. PLoS Comput Biol. How does a small molecule bind at a cryptic binding site?

[2] Sreyashi Majumdar, et al. Curr Top Med Chem. Modulating Interleukins and their Receptors Interactions with Small Chemicals Using In Silico Approach for Asthma

[3] Christopher D Thanos, et al. Proc Natl Acad Sci U S A. Hot-spot mimicry of a cytokine receptor by a small molecule

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  Catalog
Abmole Inhibitor Catalog




Keywords: SP4206  supplier, IL Receptor/Related, inhibitors, activators

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