About 1 result found for searched term "SNIPER(ER)-87 " (0.123 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M29371 | SNIPER(ER)-87 | PROTAC |
| SNIPER(ER)-87 consists of an inhibitor of apoptosis protein (IAP) ligand LCL161 derivative that is conjugated to the estrogen receptor α (ERα) ligand 4-hydroxytamoxifen by a PEG linker, and efficiently degrades the ERα protein (IC50=0.097 μM). SNIPER(ER)-87 preferentially recruits XIAP to ERα in the cells, and XIAP is the primary E3 ubiquitin ligase responsible for the SNIPER(ER)-87-induced ERα degradation. | ||
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