SIRT6-IN-2 - Search Results | AbMole BioScience

About 6 results found for searched term "SIRT6-IN-2" (0.167 seconds)

Cat.No.	Name	Target
M6254	OSS_128167	Sirtuin
	SIRT6-IN-1; OSS-128167
	OSS_128167 is a specific SIRT6 inhibitor with IC50 values of 89, 1578 and 751 μM for SIRT6, SIRT1 and SIRT2, respectively.
M41606	SIRT6-IN-2	Sirtuin
	SIRT6-IN-2 is a selective SIRT6 inhibitor (IC50: 34 μM).
M11030	SRT 1720	Sirtuin
	SRT 1720 is a potent activator of the human SIRT1, EC1.5 The value is 0.16 μM and simultaneously inhibits SIRT2 and SIRT3, EC1.5 The values are 37 μM and > 300 μM, respectively.
M27669	E1231	Sirtuin
	1-{4-[2-(5-Methylfuran-2-yl)quinoline-4-carbonyl]piperazin-1-yl}ethan-1-one
	E1231 is an orally active activator of Sirtuin 1 (SIRT1) (EC50=0.83 μM), to modulate cholesterol and lipid metabolism. E1231 interactes with SIRT1 (KD=9.61 μM) and deacetylated liver X receptor-alpha (LXRα), and increases ATP-binding cassette transporter A1 (ABCA1) expression. E1231 also reduces atherosclerotic plaque development in ApoE-/- mice model. E1231 can be used for research in cholesterol and lipid disorder-related diseases.
M27932	SRTCX1002	Sirtuin
	SRTCX1002 is a potent activator of SIRT1 (STAC), suppresses inflammatory responses through promotion of p65 deacetylation and inhibition of NF-κB Activity. SRTCX1002 suppresses stimuli-induced NF-κB transcriptional activation and LPS-induced TNFα secretion with IC50s of 0.71 and 7.58 µM, respectively.
M41729	SIRT2/6-IN-1	Sirtuin
	SIRT2/6-IN-1 is a SIRT6/SIRT2 inhibitor, with IC50s of 106 μM and 114 μM.