About 13 results found for searched term "SGK" (0.114 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M10382 | PROTAC SGK3 degrader-1 | PROTAC |
| SGK3-PROTAC1 | ||
| PROTAC SGK3 degrader-1 (SGK3-PROTAC1) is a potent SGK3 degrader, it is a PROTAC conjugate of the 308-R SGK inhibitor with the VH032 VHL binding ligand, targeting SGK3. | ||
| M28400 | SGK1-IN-2 | SGK |
| SGK1-IN-2 (14h) is a selective SGK1 (serum and glucocorticoid regulated kinase 1) inhibitor, with an IC50 of 5 nM at 10 μM ATP concentration. | ||
| M50485 | SGKtide | Others |
| SGKtide is used as an SGK(Serum and glucocorticoid-inducible kinase) substrate. | ||
| M56791 | SGK1-IN-3 | SGK |
| SGK1-IN-3 is a potent and orally active inhibitor of SGK1. | ||
| M4708 | Herbacetin | Others |
| Herbacetin is a natural flavonoid found in flaxseed and has a variety of pharmacological activities, including antioxidant, anti-inflammatory and anticancer effects. Herbacetin is an Ornithine decarboxylase (ODC) allosteric inhibitor that binds directly to Asp44, Asp243 and Glu384 on ODC. It is also an SGK1 inhibitor. | ||
| M5325 | GSK 650394 | SGK |
| GSK650394 is a serum- and glucocorticoid-regulated kinase-1 inhibitor with IC50 of 62 nM and 103 nM for SGK1 and SGK2, respectively. | ||
| M5533 | Corticosterone | GCR |
| 17-Deoxycortisol; 11β,21-Dihydroxyprogesterone; Kendall's compound B | ||
| Corticosterone (17-Deoxycortisol) is an orally active and adrenal cortex-produced glucocorticoid, which plays an important role in regulating neuronal functions of the limbic system. Corticosterone increases the Rab-mediated AMPAR membrane traffic via SGK-induced phosphorylation of GDI. | ||
| M7683 | CKI-7 dihydrochloride | Casein Kinase |
| CKI-7 is a CK1 inhibitor; also inhibits SGK, S6K1 and MSK1. | ||
| M11404 | EMD638683 | SGK |
| EMD638683 is a highly selective SGK1 inhibitor with an IC50 value of 3 μM. | ||
| M14535 | EMD638683 R-Form | SGK |
| EMD638683 R-Form is the R-form of EMD638683. EMD638683 is a highly selective SGK1 inhibitor with IC50 of 3 μM. | ||
| M28315 | SI-113 | SGK |
| SI-113 is a SGK1 inhibitor, with an IC50 of 600 nM. SI113 induces autophagy. | ||
| M29542 | HaloPROTAC-E | SGK |
| HaloPROTAC-E is a novel HaloPROTAC potent degrader, inducing reversible degradation of two endosomally localized proteins, SGK3 and VPS34, with a DC50 of 3-10 nM, remarkably selective inducing only degradation of the Halo tagged endogenous VPS34 complex (VPS34, VPS15, Beclin1, and ATG14). | ||
| M45282 | CKI-7 free base | Casein Kinase |
| CKI-7 free base is a potent and ATP-competitive casein kinase 1 (CK1) inhibitor with an IC50 of 6 μM and a Ki of 8.5 μM. In addition, CKI-7 free base selectively inhibits Cdc7 kinase, SGK, S6K1 and MSK1. | ||
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