SD-36 - Search Results | AbMole BioScience

About 5 results found for searched term "SD-36" (0.132 seconds)

Cat.No.	Name	Target
M21159	SD-36	PROTAC
	SD-36 is a potent STAT3 PROTAC degradation agent (Kd=~50 nM) with a high selectivity compared to other STAT members. SD-36 is composed of the STAT3 inhibitor SI-109, a linker, and an analog of Cereblon ligand Lenalidomide for E3 ubiquitin ligase.
M2897	OG-L002	Histone demethylase
	OG-L002 is a potent and specific LSD1 inhibitor with IC50 of 20 nM, exhibiting 36- and 69-fold selectivity over MAO-B and MAO-A, respectively.
M21406	SI-109	STAT
	SI-109 is a potent STAT3 SH2 domain structural domain inhibitor (Ki=9 nM) with antitumor activity. si-109 effectively inhibits the transcriptional activity of STAT3 (IC50=3 μM). si-109 and the CRBN analogue lenalidomide ligand were used to design the PROTAC STAT3 degradation agent SD- 36.
M25458	UNC8153	Others
	UNC-8153
	UNC8153 is a novel NSD2-targeted degrader that potently and selectively reduces the cellular levels of both NSD2 protein and the H3K36me2 chromatin mark.
M54400	HAEGTFTSD	Glucagon Receptor
	HAEGTFTSD is a 9-residue peptide of human GLP-1 peptide or GLP-1(7-36), amide.