About 20 results found for searched term "SA 57" (0.219 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M7241 | SA 57 | Others |
| SA 57 is a potent FAAH inhibitor. | ||
| M5951 | Sarpogrelate HCl | 5-HT Receptor |
| MCI-9042 | ||
| Sarpogrelate (MCI-9042) hydrochloride, a selective 5-HT2 antagonist, with pKis of 8.52, 6.57, and 7.43 for 5-HT2A, 5-HT2B, and 5-HT2C receptors, respectively. | ||
| M6965 | MK-571 sodium salt | Others |
| MK-571 sodium salt is a selective, orally active CysLT1 receptor antagonist. MK-571 sodium is also a inhibitor of multidrug resistance-associated protein MRP4 (ABCC4) and ABCC1 (MRP1). | ||
| M8710 | Brusatol | Keap1-Nrf2 |
| (+)-Brusatol; NSC 172924 | ||
| Brusatol (NSC 172924) is a plant-derived natural quassinoid that exhibits broad cytotoxicity in cancer cultures (IC50 <1 μM against 457 cancer cell lines) by inhibiting de novo synthesis of cellular proteins (Effective conc. <50 nM in A549 cells), including NRF2. | ||
| M10842 | KAG-308 | Prostaglandin Receptor |
| KAG-308 is an effective, selective, orallyable EP4 receptor (a subtype of prostaglandin E2 receptor) agonist that inhibits colitis, promotes tissue mucosal healing, and effectively inhibits the production of TNF-α. KAG-308 for human EP4 receptors Ki value and EC50 The values were 2.57 nM and 17 nM, respectively, which were more selective than EP1, EP2, EP3, and IP receptors. | ||
| M13912 | Fimasartan | Angiotensin Receptor |
| BR-A-657 | ||
| Fimasartan(BR-A-657) is a non-peptide angiotensin II receptor antagonist used for the treatment of hypertension and heart failure. | ||
| M19979 | MitoTracker Red CMXRos | Fluorescent Dye |
| Chloromethyl-X-rosamine | ||
| Mitotracker red cmxros is a red fluorescent dye used for staining mitochondria of living cells. Mitotracker red cmxros is a cell permeable x-rosamine derivative containing a weakly thiol reactive chloromethyl functional group that marks mitochondria. The maximum excitation / emission wavelength is 579 / 599nm- At 20 ℃, it shall be sealed and dried in a dark and moisture-proof manner. | ||
| M20718 | Tubastatin A TFA | HDAC |
| Tubastatin A trifluoroacetate salt | ||
| Tubastatin A TFA (Tubastatin A trifluoroacetate salt) is a potent and selective HDAC6 inhibitor with IC50 of 15 nM in a cell-free assay. It is selective against all the other isozymes (1000-fold) except HDAC8 (57-fold). Tubastatin A promotes autophagy and increases apoptosis. | ||
| M22479 | Lisaftoclax | Bcl-2 |
| APG-2575; Bcl-2/Bcl-xl inhibitor 1 | ||
| Lisaftoclax (APG-2575) is a dual Bcl-2 and Bcl-xl inhibitor with anti-tumor activity, exhibits IC50 values of 2 nM and 5.9 nM for Bcl-2 and Bcl-xl, respectively. | ||
| M28011 | D5D-IN-326 | Others |
| D5D-IN-326 is a selective, orally active delta-5 desaturase (D5D) inhibitor, with IC50s of 72 and 22 nM for rat and human D5D in enzymic and cell-based assays, respectively, has no effect on D6D or D9D activity. D5D-IN-326 reduces insulin resistance and decreases body weight in diet-induced obese C57BL/6J mice. | ||
| M28894 | Samuraciclib | CDK |
| CT7001; ICEC0942 | ||
| Samuraciclib (CT7001) is a potent, selective, ATP-competitive and orally active CDK7 inhibitor, with an IC50 of 41 nM. Samuraciclib displays 45-, 15-, 230- and 30-fold selectivity over CDK1, CDK2 (IC50 of 578 nM), CDK5 and CDK9, respectively. Samuraciclib inhibits the growth of breast cancer cell lines with GI50 values between 0.2-0.3 µM. Samuraciclib has anti-tumor effects. | ||
| M30954 | Isavuconazonium sulfate | Antifungal |
| BAL8557-002 | ||
| Isavuconazonium sulfate (BAL8557-002), the proagent of the active triazole Isavuconazole, is an orally active antifungal agent. Isavuconazonium sulfate is used for invasive aspergillosis and mucormycosis. | ||
| M31223 | BMSpep-57 hydrochloride | PD-1/PD-L1 |
| BMSpep-57 hydrochloride is a potent and competitive macrocyclic peptide inhibitor of PD-1/PD-L1 interaction with an IC50 of 7.68 nM. BMSpep-57 hydrochloride binds to PD-L1 with Kds of 19 nM and 19.88 nM in MST and SPR assays, respectively. BMSpep-57 hydrochloride facilitates T cell function by in creasing IL-2 production in PBMCs. | ||
| M31224 | BMSpep-57 | PD-1/PD-L1 |
| BMSpep-57 is a potent and competitive macrocyclic peptide inhibitor of PD-1/PD-L1 interaction with an IC50 of 7.68 nM. BMSpep-57 binds to PD-L1 with Kds of 19 nM and 19.88 nM in MST and SPR assays, respectively. BMSpep-57 facilitates T cell function by in creasing IL-2 production in PBMCs. | ||
| M38800 | β-Hederin | Parasite |
| β-Hederin, a saponin isolated from Hedera helix L.(Araliaceae), possesses antileishmanial activity. β-Hederin exhibits IC50 values of 1.5 μM, 68 nM and 4.57 μM in L. Mexicana promastigotes, L. mexicana amastigotes and THP1 cells, respectively. | ||
| M40289 | Sanggenofuran B | Others |
| Sanggenofuran B is 2-arylbenzofuran with anti-cancer activity. Sanggenofuran B inhibits A2780 cell line with an IC50 value of 57.1 μM. Sanggenofuran B can be isolated from the root bark of Chinese Morus cathayana. | ||
| M43239 | OVA-A2 Peptide | Others |
| OVA-A2 Peptide (SAINFEKL, OVA (257-264) Variant) is a biological active peptide. | ||
| M53287 | SAMβA | PKC |
| SAMβA is conjugated to the cell permeable peptide TAT47-57. | ||
| M54360 | TAT (48-57) | Anti-infection |
| TAT (48-57) is a cell-permeable peptide, derived from HIV-1 transactivator of transcription (Tat) protein residue 48-57. | ||
| M55880 | (Rac)-Lisaftoclax | Bcl-2 |
| (Rac)-Lisaftoclax ((Rac)-APG-2575) is a Bcl-2 inhibitor that can be uesd for hematologic malignancy research. | ||
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