About 6 results found for searched term "Ribociclib-d6" (0.121 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M55447 | Ribociclib-d6 | Others |
| Ribociclib-d6 | ||
| M2218 | Ribociclib (LEE011) | CDK |
| Ribociclib | ||
| Ribociclib (LEE011) is a highly specific CDK4/6 inhibitor with IC50 values of 10 nM and 39 nM, respectively, and is 1000 times less active against cyclin B/CDK1 complex. | ||
| M4889 | Ribociclib succinate (LEE011 succinate) | CDK |
| Ribociclib succinate | ||
| Ribociclib succinate (LEE011 succinate) is an orally available cyclin-dependent kinase (CDK) inhibitor targeting cyclin D1/CDK4 and cyclin D3/CDK6 cell cycle pathway, with potential antineoplastic activity. | ||
| M13606 | Ribociclib hydrochloride | CDK |
| LEE011 hydrochloride | ||
| Ribociclib hydrochloride (LEE011 hydrochloride) is a highly specific CDK4/6 inhibitor with IC50 values of 10 nM and 39 nM, respectively, and is over 1,000-fold less potent against the cyclin B/CDK1 complex. | ||
| M13607 | Ribociclib succinate hydrate | CDK |
| LEE011 succinate hydrate | ||
| Ribociclib succinate hydrate (LEE011 succinate hydrate) is a highly specific CDK4/6 inhibitor with IC50 values of 10 nM and 39 nM, respectively, and is over 1,000-fold less potent against the cyclin B/CDK1 complex. | ||
| M29520 | BSJ-04-132 | PROTAC |
| BSJ-04-132 is a PROTAC connected by ligands for Cereblon and CDK. BSJ-04-132 is a potent and selective Ribociclib-based CDK4 degrader (PROTAC), with IC50s of 50.6 nM and 30 nM for CDK4/D1 and CDK6/D1, respectively. BSJ-04-132 does not induce CDK6 and IKZF1/3 degradation. BSJ-04-132 has anti-cancer activity. | ||
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