About 18 results found for searched term "RPI-1" (0.123 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M8146 | RPI-1 | RET |
| CS-2266 | ||
| RPI-1 is a competitive, potent ATP-dependent Ret kinase inhibitor. | ||
| M55033 | Recombinant Human Serpin A12 (E.coli, N-GST) | Cytokines and Growth Factors |
| Serine Protease Inhibitor-clade A12; Serpin A12; Visceral Adipose-Specific Serpin | ||
| Vaspin (Visceral Adipose-Specific SERPIN) is a newly described adipokine. Vaspin is also a unique insulin sensitizing adipocytokine in obesity. | ||
| M55674 | Recombinant Mouse Neuroserpin Protein (HEK293, C-His) | Cytokines and Growth Factors |
| Serpini1 | ||
| Neuroserpin, also known as SERPINI1, is a secreted protein that belongs to the serpin family. Neuroserpin is a serine protease inhibitor that inhibits plasminogen activators and plasmin but not thrombin. Neuroserpin may be involved in the formation or reorganization of synaptic connections, as well as synaptic plasticity in the adult nervous system. | ||
| M3029 | SRPIN340 | SRPK |
| SRPK inhibitor | ||
| SRPIN340 is a selective SRPK inhibitor with Ki of 0.89 μM for SRPK1, showing no significant inhibitory activity against more than 140 other kinases. | ||
| M3913 | Sophocarpine | Autophagy |
| Sophocarpine is a HERG K+ channel blocker with IC50 of 100-300 μM and Na+ channel inward current inhibitor. | ||
| M4663 | Reserpine | Animal Modeling |
| Reserpine is an inhibitor of vesicular monoamine transporter protein 2 (VMAT2) that irreversibly blocks the H+-coupled vesicular monoamine transporters, VMAT1 and VMAT2. It can be used to construct animal models of depression. | ||
| M21577 | Sirpiglenastat | Others |
| DRP-104 | ||
| Sirpiglenastat (DRP-104) is a broad acting glutamine (glutamine) antagonist. Sirpiglenastat has anticancer effects by directly targeting tumor metabolism and simultaneously inducing an effective antitumor immune response. | ||
| M22525 | Podocarpic acid | TRP Channel |
| Podocarpic acid is a natural product, which acts as a novel TRPA1 activator. | ||
| M27659 | (+)-Tetrabenazine | Monoamine Transporter |
| (+)-TBZ; (3R,11bR)-TBZ; (3R,11bR)-Tetrabenazine | ||
| (+)-Tetrabenazine ((+)-TBZ; (3R,11bR)-TBZ; (3R,11bR)-Tetrabenazine) is a reversible inhibitor of vesicular monoamine transporter 2 (VMAT-2), inhibits transport by VMAT2 with 10-fold greater potency than transport by VMAT1. target: VMAT-2 In vitro: (+)-Tetrabenazine inhibit the activity of the transporter but appear to interact differently with the protein. [2] (+)-Tetrabenazine inhibits reserpine binding to the transporter, suggesting that the sites may interact in an allosteric manner. [1] In vivo: 0.9% saline (80%) and dimethylsulfoxide (DMSO) (20%). (+)-Tetrabenazine blocks dopamine (DA) storage and depletes striatal DA; (+)-Tetrabenazine was shown to induce tremulous jaw movements (TJMs) in rats and mice. The reference dose for administration is 2.0 mg/kg.[2] | ||
| M28296 | ARN1468 | Others |
| ARN1468 (compound 5) is an orally active and potent serpins inhibitor. ARN1468 can inhibit serpins activity would set the protease free to further reduce prion accumulation. ARN1468 shows anti-prion effect in ScGT1 RML, ScGT1 22L, ScN2a RML, and ScN2a 22L cell lines, with EC50 values of 8.64, 19.3, 11.2, and 6.27 μM. | ||
| M28492 | Margatoxin | Potassium Channel |
| Margatoxin, an alpha-KTx scorpion toxin, is a high affinity inhibitor of Kv1.3 (Kd=11.7 pM). Margatoxin inhibits the Kv1.2 (Kd=6.4 pM) and Kv1.1 (Kd=4.2 nM). Margatoxin, a 39 amino-acid-long peptide, is isolated from the venom of the scorpion Centruroides margaritatus and widely used in ion channel research. | ||
| M30022 | SRPIN803 | Casein Kinase |
| SRPIN803 is a potent CK2 and SRPK1 dual inhibitor, with IC50s of 203 nM and 2.4 μM, respectively. SRPIN803 exhibits antiangiogenic activity. SRPIN803 can be used for the research of age-related macular degeneration. | ||
| M30153 | Aleplasinin | PAI-1 |
| PAZ-417 | ||
| Aleplasinin is an orally active, potent, BBB-penetrated and selective SERPINE1 (PAI-1, Plasminogen activator inhibitor-1) inhibitor. Aleplasinin increases amyloid-β (Aβ) catabolism and ameliorates amyloid-related pathology. Aleplasinin improves memory deficiency. Aleplasinin can be used for Alzheimer's disease research. | ||
| M38977 | 1,11b-Dihydro-11b-hydroxymedicarpin | IL Receptor/Related |
| Medicarpin, a natural pterocarpan, heals cortical bone defect by activation of Notch and Wnt canonical signaling pathways. Medicarpin down-regulates pro-inflammatory cytokines like TNF-α, IL-6 and IL-17A, while up-regulates anti-inflammatory cytokine IL-10 in arthritis (CIA) model of mice. | ||
| M39746 | 1-Hydroxyrutecarpine | Others |
| 1-Hydroxyrutaecarpine (compound 1a) is a hydroxy-derivative of rutaecarpine. 1-Hydroxyrutaecarpine shows cytotoxicities with ED50s of 3.72, 7.44 µg/mL for P-388 and HT-29 cells, respectively. 1-Hydroxyrutaecarpine shows antiplatelet activity. | ||
| M44663 | (-)-Isodocarpin | Melanocortin Receptor |
| (-)-Isodocarpin (Isodocarpin), a diterpenoid, is a potent melanogenesis inhibitor with an IC50 of 0.19 μM in B16 4A5 cells. | ||
| M52732 | Noxiustoxin | Potassium Channel |
| Noxiustoxin is a toxin from the venom of the Mexican scorpion Centruroides noxius which block voltage-dependent potassium channel (Kv1.3, IC50 = 360 nM), and calcium-activated potassium channel. | ||
| M55750 | Nifurpirinol | Antibiotic |
| Nifurpirinol (P-7138) is a nitroaromatic antibiotic and acts as a novel substrate for the bacterial nitroreductase (NTR) enzyme. | ||
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