About 16 results found for searched term "RPI-1" (0.127 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M8146 | RPI-1 | RET |
| CS-2266 | ||
| RPI-1 is a competitive, potent ATP-dependent Ret kinase inhibitor. | ||
| M55033 | Recombinant Human Serpin A12 (E.coli, N-GST) | Recombinant Proteins |
| Serine Protease Inhibitor-clade A12; Serpin A12; Visceral Adipose-Specific Serpin | ||
| Vaspin (Visceral Adipose-Specific SERPIN) is a newly described adipokine. Vaspin is also a unique insulin sensitizing adipocytokine in obesity. | ||
| M3029 | SRPIN340 | SRPK |
| SRPK inhibitor | ||
| SRPIN340 is a selective SRPK inhibitor with Ki of 0.89 μM for SRPK1, showing no significant inhibitory activity against more than 140 other kinases. | ||
| M3913 | Sophocarpine | Autophagy |
| Sophocarpine is a HERG K+ channel blocker with IC50 of 100-300 μM and Na+ channel inward current inhibitor. | ||
| M4663 | Reserpine | Animal Modeling |
| Reserpine is an inhibitor of vesicular monoamine transporter protein 2 (VMAT2) that irreversibly blocks the H+-coupled vesicular monoamine transporters, VMAT1 and VMAT2. It can be used to construct animal models of depression. | ||
| M21577 | Sirpiglenastat | Others |
| DRP-104 | ||
| Sirpiglenastat (DRP-104) is a broad acting glutamine (glutamine) antagonist. Sirpiglenastat has anticancer effects by directly targeting tumor metabolism and simultaneously inducing an effective antitumor immune response. | ||
| M22525 | Podocarpic acid | TRP Channel |
| Podocarpic acid is a natural product, which acts as a novel TRPA1 activator. | ||
| M27659 | (+)-Tetrabenazine | Monoamine Transporter |
| (+)-TBZ; (3R,11bR)-TBZ; (3R,11bR)-Tetrabenazine | ||
| (+)-Tetrabenazine ((+)-TBZ; (3R,11bR)-TBZ; (3R,11bR)-Tetrabenazine) is a reversible inhibitor of vesicular monoamine transporter 2 (VMAT-2), inhibits transport by VMAT2 with 10-fold greater potency than transport by VMAT1. target: VMAT-2 In vitro: (+)-Tetrabenazine inhibit the activity of the transporter but appear to interact differently with the protein. [2] (+)-Tetrabenazine inhibits reserpine binding to the transporter, suggesting that the sites may interact in an allosteric manner. [1] In vivo: 0.9% saline (80%) and dimethylsulfoxide (DMSO) (20%). (+)-Tetrabenazine blocks dopamine (DA) storage and depletes striatal DA; (+)-Tetrabenazine was shown to induce tremulous jaw movements (TJMs) in rats and mice. The reference dose for administration is 2.0 mg/kg.[2] | ||
| M28296 | ARN1468 | Others |
| ARN1468 (compound 5) is an orally active and potent serpins inhibitor. ARN1468 can inhibit serpins activity would set the protease free to further reduce prion accumulation. ARN1468 shows anti-prion effect in ScGT1 RML, ScGT1 22L, ScN2a RML, and ScN2a 22L cell lines, with EC50 values of 8.64, 19.3, 11.2, and 6.27 μM. | ||
| M28492 | Margatoxin | Potassium Channel |
| Margatoxin, an alpha-KTx scorpion toxin, is a high affinity inhibitor of Kv1.3 (Kd=11.7 pM). Margatoxin inhibits the Kv1.2 (Kd=6.4 pM) and Kv1.1 (Kd=4.2 nM). Margatoxin, a 39 amino-acid-long peptide, is isolated from the venom of the scorpion Centruroides margaritatus and widely used in ion channel research. | ||
| M30022 | SRPIN803 | Casein Kinase |
| SRPIN803 is a potent CK2 and SRPK1 dual inhibitor, with IC50s of 203 nM and 2.4 μM, respectively. SRPIN803 exhibits antiangiogenic activity. SRPIN803 can be used for the research of age-related macular degeneration. | ||
| M30153 | Aleplasinin | PAI-1 |
| PAZ-417 | ||
| Aleplasinin is an orally active, potent, BBB-penetrated and selective SERPINE1 (PAI-1, Plasminogen activator inhibitor-1) inhibitor. Aleplasinin increases amyloid-β (Aβ) catabolism and ameliorates amyloid-related pathology. Aleplasinin improves memory deficiency. Aleplasinin can be used for Alzheimer's disease research. | ||
| M38977 | 1,11b-Dihydro-11b-hydroxymedicarpin | IL Receptor/Related |
| Medicarpin, a natural pterocarpan, heals cortical bone defect by activation of Notch and Wnt canonical signaling pathways. Medicarpin down-regulates pro-inflammatory cytokines like TNF-α, IL-6 and IL-17A, while up-regulates anti-inflammatory cytokine IL-10 in arthritis (CIA) model of mice. | ||
| M39746 | 1-Hydroxyrutecarpine | Others |
| 1-Hydroxyrutaecarpine (compound 1a) is a hydroxy-derivative of rutaecarpine. 1-Hydroxyrutaecarpine shows cytotoxicities with ED50s of 3.72, 7.44 µg/mL for P-388 and HT-29 cells, respectively. 1-Hydroxyrutaecarpine shows antiplatelet activity. | ||
| M44663 | (-)-Isodocarpin | Melanocortin Receptor |
| (-)-Isodocarpin (Isodocarpin), a diterpenoid, is a potent melanogenesis inhibitor with an IC50 of 0.19 μM in B16 4A5 cells. | ||
| M52732 | Noxiustoxin | Potassium Channel |
| Noxiustoxin is a toxin from the venom of the Mexican scorpion Centruroides noxius which block voltage-dependent potassium channel (Kv1.3, IC50 = 360 nM), and calcium-activated potassium channel. | ||
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