About 30 results found for searched term "ROCK inhibitor-2" (0.11 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M13731 | ROCK inhibitor-2 | ROCK |
| ROCK inhibitor-2 is a selective dual ROCK1 and ROCK2 inhibitor with IC50s of 17 nM and 2 nM, respectively. | ||
| M1856 | Thiazovivin | ROCK |
| Thiazovivin is a selective small molecule Rho-associated kinase (ROCK) inhibitor which significantly improves (200-fold) the efficiency of iPSC generation from human fibroblasts. | ||
| M5123 | Y-39983 dihydrochloride | ROCK |
| Y-33075 dihydrochloride | ||
| Y-39983 (Y-33075) dihydrochloride is a selective ROCK inhibitor with an IC50 of 3.6 nM, derived from Y-27632, inhibited ROCK more potently than Y-27632. | ||
| M5168 | GSK269962A | ROCK |
| GSK 269962 | ||
| GSK269962A is a potent ROCK inhibitor with IC50 values of 1.6 and 4 nM for recombinant human ROCK1 and ROCK2, respectively. | ||
| M5260 | Hydroxyfasudil hydrochloride | ROCK |
| HA-1100 HCl | ||
| Hydroxyfasudil (HA-1100), an active metabolite of fasudil hydrochloride, is a specific Rho-kinase(ROCK) inhibitor with IC50 values of 0.73 μM and 0.72 μM for ROCK1 and ROCK2, respectively. | ||
| M5339 | SR 3677 | ROCK |
| SR-3677 is a new potent and selective ROCK-II inhibitor with an IC50 of ~3 nM in enzyme and cell based assays; IC50 for ROCK-I is 56 ± 12 nM. | ||
| M5933 | Ripasudil (K-115) dihydrate | ROCK |
| K-115 | ||
| Ripasudil (K-115) hydrochloride dihydrate is potent ROCK inhibitor with IC50 of 51 nM and 19 nM for ROCK1 and ROCK2, respectively, used for the treatment of glaucoma and ocular hypertension. | ||
| M9678 | SAR407899 | ROCK |
| SAR407899 is a potent and selective, ATP-competitive ROCK inhibitor with IC50 of 135 nM for ROCK-2, and Kis of 36 nM and 41 nM for human and rat ROCK-2, respectively. | ||
| M11034 | Netarsudil (AR-13324) 2HCl | ROCK |
| AR-13324 | ||
| Netarsudil (AR-13324) is a Rho-kinase (ROCK) inhibitor with Ki values of 0.2-10.3 nM with potential intraocular pressure (IOP) lowering activity that inhibits both the ROCK and Rho pathways and increases atrial humor (AH) outflow and lowers IOP via the trabecular pathway, and may be used in glaucoma-related studies. | ||
| M13726 | Chroman 1 | ROCK |
| Chroman 1 is a highly potent and selective ROCK inhibitor. Chroman 1 is more potent against ROCK2 (IC50=1 pM) than ROCK1 (IC50=52 pM). Chroman 1 also has inhibitory activity against MRCK, with an IC50 of 150 nM. | ||
| M13727 | H-1152 dihydrochloride | ROCK |
| H-1152 dihydrochloride is a membrane-permeable and selective ROCK inhibitor, with a Ki value of 1.6 nM, and an IC50 value of 12 nM for ROCK2. | ||
| M13728 | Hydroxyfasudil | ROCK |
| HA-1100 | ||
| Hydroxyfasudil is a ROCK inhibitor, with IC50s of 0.73 and 0.72 μM for ROCK1 and ROCK2, respectively. | ||
| M13730 | RKI-1447 dihydrochloride | ROCK |
| RKI 1447 dihydrochloride is a potent and selective ROCK inhibitor with IC50s of 14.5 and 6.2 nM for ROCK1 and ROCK2, respectively. RKI 1447 dihydrochloride suppresses colorectal carcinoma cell growth and promotes apoptosis. | ||
| M13732 | SAR407899 hydrochloride | ROCK |
| SAR407899 hydrochloride is a selective, potent and ATP-competitive ROCK inhibitor, with an IC50 of 135 nM for ROCK-2, and Kis of 36 nM and 41 nM for human and rat ROCK-2, respectively. | ||
| M13733 | Y-33075 | ROCK |
| Y 39983 | ||
| Y-33075 is a selective ROCK inhibitor derived from Y-27632, and is more potent than Y-27632, with an IC50 of 3.6 nM. | ||
| M20999 | Y-27632 | ROCK |
| Y-27632 is a selective ROCK1 (p160ROCK) inhibitor with Ki of 140 nM in a cell-free assay, exhibits >200-fold selectivity over other kinases, including PKC, cAMP-dependent protein kinase, MLCK and PAK. | ||
| M28188 | Sovesudil | ROCK |
| PHP-201; AMA0076 | ||
| Sovesudil (PHP-201) is a potent, ATP-competitive, locally acting Rho kinase (ROCK) inhibitor with IC50s of 3.7 and 2.3 nM for ROCK-I and ROCK-II, respectively. Sovesudil lowers intraocular pressure (IOP) without inducing hyperemia. | ||
| M28366 | Verosudil | ROCK |
| AR-12286 | ||
| Verosudil (AR-12286) is a potent, selective Rho-kinase (ROCK) inhibitor with Kis of 2 and 2 nM for ROCK1 and ROCK2, respectively. AR-12286 lowers intraocular pressure (IOP) primarily by increasing aqueous humour outflow through the trabecular meshwork. | ||
| M30754 | PT-262 | ROCK |
| PT-262 is a potent ROCK inhibitor with an IC50 value of around 5 μM. PT-262 induces the loss of mitochondrial membrane potential and elevates the caspase-3 activation and apoptosis. PT-262 inhibits the ERK and CDC2 phosphorylation via a p53-independent pathway. PT-262 blocks cytoskeleton function and cell migration. PT-262 has anti-cancer activity. | ||
| M31008 | Sovesudil hydrochloride | ROCK |
| PHP-201 hydrochloride; AMA0076 hydrochloride | ||
| Sovesudil (PHP-201) hydrochloride is a potent, ATP-competitive, locally acting Rho kinase (ROCK) inhibitor with IC50s of 3.7 and 2.3 nM for ROCK-I and ROCK-II, respectively. Sovesudil hydrochloride lowers intraocular pressure (IOP) without inducing hyperemia. | ||
| M41592 | THK01 | ROCK |
| THK01 is a potent ROCK2 inhibitor with IC50 values of 5.7 and 923 nM for ROCK2 and ROCK1, respectively. | ||
| M49525 | 3-(4-Pyridyl)indole | ROCK |
| 3-(4-Pyridyl)indole (Rockout) is a Rho-kinase (ROCK) inhibitor, with an IC50 of 25 μM. | ||
| M49533 | GSK269962A hydrochloride | ROCK |
| GSK269962A hydrochloride (GSK 269962 hydrochloride) is a potent ROCK inhibitor with IC50s of 1.6 and 4 nM for recombinant human ROCK1 and ROCK2 respectively. | ||
| M49535 | HSD1590 | ROCK |
| HSD1590 is potent ROCK inhibitor, with IC50s of 1.22 and 0.51 nM for ROCK1 and ROCK2, respectively. | ||
| M49536 | Rho-Kinase-IN-1 | ROCK |
| Rho-Kinase-IN-1 is a Rho kinase (ROCK) inhibitor (Ki values of 30.5 and 3.9 nM for ROCK1 and ROCK2, respectively) extracted from US20090325960A1, compound 1.008. | ||
| M49537 | Rho-Kinase-IN-2 | ROCK |
| Rho-Kinase-IN-2 is an orally active, selective, and central nervous system (CNS)-penetrant Rho Kinase (ROCK) inhibitor (ROCK2 IC50=3 nM). | ||
| M49538 | ROCK2-IN-5 | ROCK |
| ROCK2-IN-5 is a hybrid compound containing structural fragments of the Rho kinase inhibitor fasudil and the NRF2 inducers caffeic and ferulic acids. | ||
| M49539 | ROCK2-IN-7 | ROCK |
| ROCK2-IN-7 is a kinase inhibitor targeting to ROCK2. | ||
| M49540 | ROCK-IN-1 | ROCK |
| ROCK-IN-1 is a potent inhibitor of ROCK, with an IC50 of 1.2 nM for ROCK2. | ||
| M49541 | ROCK-IN-32 | ROCK |
| ROCK-IN-32 is a ROCK inhibitor, with an IC50 value of 11 nM for ROCK2. | ||
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