RM-032 - Search Results | AbMole BioScience

About 3 results found for searched term "RM-032" (0.127 seconds)

Cat.No.	Name	Target
M49368	RM-032	Ras
	RM-032 is an orally active KRAS inhibitor that covalently binds to KRAS G12C and procyclin A to inhibit RAS pathway signaling and cell proliferation in KRAS G12C tumor cells.
M43803	Zidesamtinib	ROS Kinase
	NVL-520
	Zidesamtinib is a potent, selective, orally active and blood-brain barrier permeable inhibitor of multiple ROS1 fusion and resistance mutations, with IC50 values of 0.7 and 7.9 nM for wild-type ROS1 and ROS1 G2032R, respectively, and does not inhibit TRK.May be useful in studies related to non-small cell lung cancer and other solid tumors.
M54576	ADS032	NLR
	ADS032 is a dual inhibitor of NLRP1 and NLRP3 that rapidly, reversibly and stably inhibits inflammasome formation and reduces NLPR1 and NLRP3 activation of human-derived macrophages and bronchial epithelial cells to secrete and mature IL-1β and TNF-α, and reduces NLRP3-induced ASC speck formation. In addition, ADS032 protects mice from the deadly influenza A virus, reduces lung inflammation and improves survival.