About 7 results found for searched term "RET-IN-23" (0.131 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M43520 | RET-IN-23 | RET |
| RET-IN-23 is a potent and orally active RET inhibitor with IC50 values of 1.32, 2.50, 6.54, 1.03, 1.47 nM for RET-WT, RET-CCDC6, RET-V804L, RET-V804M, RET-M918T, respectively. | ||
| M2130 | LY-411575 | Gamma-secretase/Beta-secretase |
| LSN-411575 | ||
| LY-411575 is potent and selective small molecule γ-secretase inhibitor with IC50 of 0.1 nM for APP23 and APP51/16 primary neurons. | ||
| M2172 | LY2811376 | Gamma-secretase/Beta-secretase |
| LY2811376 is an orally available, non-peptidic β-secretase inhibitor with IC50 of 239 nM-249 nM. | ||
| M7500 | YK 3-237 | Sirtuin |
| YK 3-237 is a boronic acid chalcone analog of combretastatin a4 (CA-4) and a SIRT1 activator that targets mutant p53. YK 3-237 can reduce the acetylation of mutant p53 protein by activating the SIRT1 enzyme, resulting in a significant decrease in the level of mutant p53 protein. YK-3-237 showed antiproliferative activity against tumor cells containing mutant p53 protein. | ||
| M8199 | SR11237 | RAR/RXR |
| SR11237 is a retinoid X receptor (RXR) selective agonist without any RAR activity that leads to the formation of RXR/RXR homodimers and activation of reporter genes containing RXR response elements. In addition, SR11237 significantly promotes reprogramming. | ||
| M24780 | Flotetuzumab | Others |
| MGD006 S80880 | ||
| Flotetuzumab (MGD006; S80880) is an investigational CD123/CD3 bispecific dual-affinity retargeting antibody (DART) molecule. Flotetuzumab reactivates T cells by simultaneously binding to CD123 in target cells and CD3 in effector T cells, leading to T-cell-mediated cytotoxicity in target cells. Flotetuzumab shows inhibitory effect on a mouse model of patient-derived xenograft (PDX) in acute myeloid leukemia (AML). | ||
| M29487 | Izumerogant | ROR |
| IMU-935 | ||
| Izumerogant (IMU-935) is an inverse agonist of retinoid-related orphan receptor-gamma (RORγ). Izumerogant (compound 123) also potently inhibits IL-17A, IL-17F and IFN-γ activity with IC50s <50 nM. | ||
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