About 7 results found for searched term "RET-IN-22" (0.144 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M43521 | RET-IN-22 | RET |
| RET-IN-22 is a potent, selective and orally active RET inhibitor with an IC50 of 20.9 nM and 18.3 nM for wild-type RET and RET-V804M, respectively. | ||
| M2241 | Adapalene | RAR/RXR |
| Differin | ||
| Adapalene is a third-generation topical retinoid, it is a potent RAR agonist, with AC50 values of 2.3 nM, 9.3 nM, and 22 nM for RARβ, RARγ, RARα, respectively. Adapalene also inhibits the enzymatic activity of GOT1 in a non-competitive manner. | ||
| M4847 | Tafamidis | Transthyretin (TTR) |
| Fx-1006A, Vyndaqel | ||
| Tafamidis is a potent and selective transthyretin kinetic stabilizer that inhibits the amyloid cascade, with EC50s of 2.7-3.2 μM to the mutumant homotetramers V30M-TTR, V122I-TTR and wild type WT-TTR. | ||
| M10764 | Acoramidis hydrochloride | Transthyretin (TTR) |
| AG10 hydrochloride | ||
| Acoramidis (AG10) hydrochloride is an orally active, selective stabilizer of the thyroxine transporter (TTR (transthyretin)) that is effective against both wild-type and V1221 mutant types. Acoramidis (AG10) hydrochloride can be used for the study of transthyroxine amyloidosis. | ||
| M14778 | Tafamidis meglumine | Transthyretin (TTR) |
| Fx-1006A | ||
| Tafamidis meglumine (Fx-1006A) is a potent and selective transthyretin (TTR) stabilizer, shows comparable potency and efficacy to the mutumant homotetramers V30M-TTR, V122I-TTR and wild type WT-TTR, with EC50s of 2.7-3.2 μM. | ||
| M25425 | Recombinant Human CXCL10 (Mammalian, C-Fc-6His) | Recombinant Proteins |
| C-X-C Motif Chemokine 10; IP-10 | ||
| Human C-X-C Motif Chemokine Ligand 10 (CXCL10) is a non-ELR chemokine secreted by various cell types, such as monocytes, endothelial cells and fibroblasts, in response to IFN-γ. Recombinant Human CXCL10 is produced by Mammalian expression system and the target gene encoding Val22-Pro98 is expressed with a human IgG1 Fc, 6His tag at the C-terminus. | ||
| M31134 | Recombinant Mouse Prolactin/PRL Protein (Mammalian, C-6His) | Recombinant Proteins |
| Growth hormone a1; Gha1 | ||
| Prolactin (PRL) is a secreted neuroendocrine pituitary hormone that acts primarily on the mammary gland to promote lactation. Recombinant Mouse Prolactin/PRL Protein is produced by Mammalian expression system and the target gene encoding Leu32-Cys228 is expressed with a 6His tag at the C-terminus. | ||
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