About 28 results found for searched term "Pyruvate Kinase" (0.126 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M2865 | Sodium Monofluorophosphate | Pyruvate Kinase |
| Monofluorophosphate is a competitive inhibitor of pyruvate kinase and alkaline phosphatase with Ki of 3.4 mM and 69 μM, respectively, which also irreversibly inhibits phosphorylase phosphatase with Ki of 0.5 mM. | ||
| M4240 | Shikonin | TNF Receptor |
| C.I. 75535; Isoarnebin 4; CAS# 54952-43-1 | ||
| Shikonin (C.I. 75535, Anchusin, Anchusa acid, Alkanna Red, Isoarnebin 4, NSC 252844) is an effective and specific inhibitor of Pyruvate kinase M2 (PKM2). Shikonin is the main ingredient of Lithosia, a Chinese herb with a variety of biological activities. Shikonin acts as an anti-inflammatory by inhibiting tumor necrosis factor-α (TNF-α), Proteasome can inhibit the activation of nuclear factor-κB (NF-κB) signaling pathway. | ||
| M6261 | PKM2-IN-1 | Pyruvate Kinase |
| PKM2 inhibitor; compound 3k | ||
| PKM2-IN-1 (compound 3k) is a pyruvate kinase M2 (PKM2) inhibitor with an IC50 of 2.95 μM. The IC50 value for PKM1 is 4-5-fold higher than that for PKM2. | ||
| M6656 | DCA | Others |
| Sodium dichloroacetate | ||
| DCA (Sodium dichloroacetate) is a mitochondrial pyruvate dehydrogenase kinase (PDK) inhibitor. | ||
| M6857 | JX 06 | Others |
| JX 06 is a potent and selective pyruvate dehydrogenase kinase (PDK) 1/2/3 inhibitor. | ||
| M8088 | PF-06284674 | Others |
| PF-06284674 is a cell permeable, potent and selective M2 isoform of pyruvate kinase (PKM2) activator. | ||
| M9001 | ML-265 (TEPP-46) | Pyruvate Kinase |
| TEPP-46; ML265 | ||
| Ml-265 (TEPP-46) is an effective activator of pyruvate kinase M2 (PKM2). | ||
| M9034 | Mitapivat (AG-348) | Pyruvate Kinase |
| PKR-IN-1; PKM2 activator 1020; Pyrukynd； AG-348 | ||
| Mitapivat (AG-348) is the first-in-class, oral effective pyruvate kinase small molecule allosteric activator. Mitapivat (AG-348) is active against wild-type and various mutated PKR enzymes, and promotes healthy red blood cell generation by activating mutated PKR to increase ATP levels. | ||
| M9680 | 3-Bromopyruvate (3-Bromopyruvic acid) | Others |
| Hexokinase II Inhibitor II; 3-BP | ||
| 3-Bromopyruvate (3-Bromopyruvic acid) is a hexokinase II inhibitor, which is an effective antitumor agent on the hepatoma cells. | ||
| M14523 | DASA-58 | Pyruvate Kinase |
| DASA-58 is a potent activator of pyruvate kinase M2 (PKM2) with an AC90 of 680 nM, and an AC50 of 38 nM. | ||
| M19971 | Phosphoenolpyruvic acid cyclohexylammonium salt | Others |
| 2-(Phosphonooxy)-2-propenoic acid monopotassium salt | ||
| Phospho(enol)pyruvic acid (PEP) is involved in glycolysis and gluconeogenesis. In glycolysis, PEP is metabolized by pyruvate kinase to yield pyruvate. In plants, PEP is involved in the formation of aromatic amino acids as well as in the carbon fixation pathway. | ||
| M20038 | M77976 | PDHK |
| M77976 is a specific ATP-competitive inhibitor of PDK4 (pyruvate dehydrogenase kinase isoforms 4), with an IC50 of 648 μM. M77976 is potential for the research of obesity and diabetes. | ||
| M20178 | WAY-384934 | Others |
| WAY-384934 is a inhibitor of pyruvate kinase | ||
| M20322 | WAY-332616 | Others |
| WAY-332616 is a inhibitor of pyruvate kinase. | ||
| M20379 | WAY-332647 | Others |
| WAY-332647 is a inhibitor of pyruvate kinase. | ||
| M21044 | DL-Serine | Others |
| DL-Serine is a non-essential amino acid and a natural ligand and allosteric activator of pyruvate kinase M2. DL-Serine has antiviral activity against the multiplication of tobacco mosaic virus (TMV). | ||
| M21076 | Etavopivat | Pyruvate Kinase |
| FT-4202 | ||
| Etavopivat, an oral erythrocyte pyruvate kinase activator, is being developed for sickle cell disease and other hemoglobinopathies, previously reported in 2019. | ||
| M21648 | PDK4-IN-1 hydrochloride | Apoptosis |
| PDK4-IN-1 hydrochloride is an anthraquinone derivative and a potent and orally active pyruvate dehydrogenase kinase 4 (PDK4) inhibitor with an IC50 value of 84 nM. PDK4-IN-1 hydrochloride potently represses cellular transformation and cellular proliferation and induces apoptosis. | ||
| M28462 | Leelamine | Cannabinoid |
| Leelamine is a weak agonist of cannabinoid receptors CB1 and CB2. Leelamine also inhibits pyruvate dehydrogenase kinases (PDKs). Leelamine exhibits anti-tumor activity. | ||
| M28603 | PS10 | PDHK |
| PS10 is a novel, potent and ATP-competitive pan-PDK inhibitor, inhibits all PDK isoforms with IC50 of 0.8 μM, 0.76 μM, 2.1 μM and 21.3 μM for PDK2, PDK4, PDK1, and PDK3, respectively. PS10 shows high affinity for PDK2 (Kd= 239 nM) than for Hsp90 (Kd= 47 μM). PS10 improves glucose tolerance, stimulates myocardial carbohydrate oxidation in diet-induced obesity. PS10 has the potential for the investigation of diabetic cardiomyopathy.PDK: pyruvate dehydrogenase kinase | ||
| M28806 | VER-246608 | PDHK |
| VER-246608 is a potent and ATP-competitive inhibitor of pyruvate dehydrogenase kinase (PDK) with IC50s of 35 nM, 40 nM, 84 nM, and 91 nM for PDK-1, PDK-3, PDK-2, and PDK-4, respectively. | ||
| M30913 | TM-1 | PDHK |
| TM-1 is a potent inhibitor of pyruvate dehydrogenase kinase (PDHK1). TM-1 inhibits PDHK1 and PDHK2 with IC50s of 2.97 μM and 5.2 μM, respectively. TM-1 blocks pyruvate dehydrogenase complex (PDHC) phosphorylation, and inhibits cell proliferation. | ||
| M31415 | AG-946 | Pyruvate Kinase |
| AG-946 is an orally active pyruvate kinase (PK) variant activator for studies related to sickle cell anemia and myelodysplastic syndromes. | ||
| M40807 | KPLH1130 | PDHK |
| KPLH1130 is a pyruvate dehydrogenase kinase (PDK)-specific inhibitor that blocks macrophage polarization, attenuates inflammatory responses, and improves glucose tolerance in mice fed a high-fat diet. | ||
| M42534 | PDK-IN-1 | PDHK |
| PDK-IN-1 is a pyruvate dehydrogenase kinase (PDK) inhibitor. | ||
| M42594 | CIAC001 | Pyruvate Kinase |
| CIAC001 is a Pyruvate Kinase PKM2 inhibitor with anti-neuroinflammatory activity. | ||
| M42595 | PKR activator 4 | Pyruvate Kinase |
| PKR activator 4 is a potent pyruvate kinase R (PKR) activator. | ||
| M55017 | SKF-34288 hydrochloride | PEPCK |
| 3-Mercaptopicolinic acid hydrochloride; 3-MPA hydrochloride | ||
| SKF-34288 (3-Mercaptopicolinic acid) hydrochloride is an orally active phosphoenolpyruvate carboxykinase (PEPCK) inhibitor (Ki = 2-9 μM). SKF-34288 hydrochloride is a potent hypoglycemic agent by inhibiting glucose synthesis. | ||
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