About 28 results found for searched term "Proteinase K" (0.156 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M1542 | Proteinase K | Enzymes & Coenzymes |
| Proteinase K is used for digesting various proteins and common molecular biology, cell biology and other related experiments, such as genomic DNA extraction, enzyme digestion and removal. | ||
| M15012 | Recombinant Human TIMP-2 (HEK293,C-6His) | Cytokines and Growth Factors |
| Metalloproteinase Inhibitor 2; CSC-21K | ||
| TIMP-2 is a non N-glycosylated protein with a molecular mass of 22 kDa. It produced by a wide range of cell types, which inhibits MMPs non-covalently by the formation of binary complexes and irreversibly inactivates them by binding to their catalytic zinc cofactor. TIMP-2 also has erythroid‑potentiating and cell growth promoting activities. | ||
| M21336 | Recombinant Human MMP-9 (HEK293, C-6His) | Enzymes & Regulators |
| Matrix metalloproteinase-9; 92 kDa gelatinase; 92 kDa type IV collagenase | ||
| Recombinant human matrix metalloproteinase-9 is produced by a mammalian expression system and the target gene encoding Ala19-Asp707 has a 6His tag at the C-terminus. The proenzyme needs to be activated by APMA to form the active form. Protein ID: AAH06093.1. | ||
| M3636 | Leupeptin hemisulfate | Cathepsin |
| Leupeptin hemisulfate hemisulfate is the reversible inhibitor of lysosomal serine and cysteine proteinases; Leupeptin; inhibition of cathepsin B(Ki=6 nM), calpain(Ki=10 nM), trypsin (Ki=35 nM), plasmin (Ki=3.4 μM) and kallikrein (Ki=19 μM) had no effect on chymotrypsin, elastase, renin, or pepsin. | ||
| M4079 | (R)Ginsenoside-Rh2 | MMP |
| 20(R)-Ginsenoside Rh2, a matrix metalloproteinase (MMP) inhibitor, acts as an anti-proliferative agent in cells. It has anticancer effects by blocking cell proliferation and causing G1 phase arrest. 20(R)-Ginsenoside Rh2 induces apoptosis and has anti-inflammatory and antioxidant activities. 20(R)-Ginsenoside Rh2 inhibited the replication and proliferation of mouse and human γ herpevirus 68 (MHV-68) with an IC50 of 2.77 μM against mouse MHV-68. | ||
| M4086 | Ginsenoside-F4 | Apoptosis |
| Ginsenoside F4 (GF4), Ginsenoside, isolated from Panax notoginseng or red ginseng. Ginsenoside F4 (GF4) can inhibit human lymphocytic tumor JK cells by inducing apoptosis. Ginsenoside F4 (GF4) inhibited the expression of matrix metalloproteinase 13 (MMP 13) in IL-1β -treated chondrocytes, blocked cartilage damage in rabbit cartilage tissue culture, and prevented cartilage collagen matrix decomposition in pathological tissues. | ||
| M7542 | SBC-115076 | PCSK9 |
| Sbc-115076 is an effective inhibitor of the preprotein invertase Bacillus subtilis proteinase/Kexin 9 (PCSK9). PCSK9 is a preprotein invertase that plays an important role in LDL receptor metabolism. | ||
| M14049 | PAR-4 Agonist Peptide, amide TFA | PAR |
| PAR-4-AP TFA; AY-NH2 TFA | ||
| PAR-4 Agonist Peptide, amide TFA (PAR-4-AP TFA; AY-NH2 TFA) is a proteinase-activated receptor-4 (PAR-4) agonist, which has no effect on either PAR-1 or PAR-2 and whose effects are blocked by a PAR-4 antagonist. | ||
| M15098 | Recombinant Human PCSK9 (HEK293,C-6His) | Cytokines and Growth Factors |
| Proprotein Convertase Subtilisin/Kexin Type 9 | ||
| Human Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) is a secretory subtilase belonging to the proteinase K subfamily. PCSK9 binds with low-density lipoprotein receptor (LDLR) and plays a major regulatory role in cholesterol homeostasis. Inhibition of PCSK9 function by preventing PCSK9/LDLR interaction is currently being explored as a means of lowering cholesterol levels. Accession #: Q8NBP7. | ||
| M21547 | Recombinant Mouse PCSK9 (HEK293, C-6His) | Cytokines and Growth Factors |
| Proprotein Convertase Subtilisin/Kexin Type 9 | ||
| Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) is a secretory subtilase belonging to the proteinase K subfamily. PCSK9 binds with low-density lipoprotein receptor (LDLR) and plays a major regulatory role in cholesterol homeostasis. PCSK9 also plays a role in neural development. | ||
| M21684 | Recombinant Human MMP-3 (HEK293, C-6His) | Enzymes & Regulators |
| Matrix metalloproteinase-3 | ||
| MMP3 is a member of the matrix metalloproteinase (MMP) family whose members are involved in the breakdown of extracellular matrix in normal physiological processes. Recombinant Human Matrix Metalloproteinase-3 is produced by Mammalian expression system and the target gene encoding Tyr18-Cys477 is expressed with a 6His tag at the C-terminus.The proenzyme needs to be activated by Chymotrypsin for an activated form. | ||
| M21685 | Recombinant Human MMP-1 (HEK293, C-6His) | Enzymes & Regulators |
| Matrix Metalloproteinase-1 | ||
| Matrix Metalloproteinase-1 (MMP-1) is expressed by fibroblasts, keratinocytes, endothelial cells, monocytes and macrophages. MMP-1 can degrade a broad range of substrates including types I, II, III, VII, VIII, and X collagens. The target gene encoding Phe20-Asn469 is expressed with a 6His tag at the C-terminus.The proenzyme needs to be activated by APMA for an activated form. | ||
| M28896 | ND-336 | MMP |
| ND-336 is a selective inhibitor of matrix metalloproteinase (MMP)-2, MMP-9, and MMP-14, with Kis of 85, 150, and 120 nM, respectively. ND-336 accelerates diabetic wound healing in mice by lowering inflammation and by enhancing angiogenesis and re-epithelialization of the wound. | ||
| M30492 | (R)-TAPI-2 | Others |
| (R)-TNF Protease Inhibitor 2 | ||
| (R)-TAPI-2 is the isomer of TAPI-2. TAPI-2 (TNF Protease Inhibitor 2) is a broad-spectrum inhibitor of matrix metalloprotease (MMP), tumour necrosis factorα-converting enzyme (TACE) and a disintegrin and metalloproteinase (ADAM), with an IC50 of 20 μM for MMP. TAPI-2 blocks the entry of infectious SARS-CoV. | ||
| M30518 | ARP-100 | MMP |
| ARP-100 is a potent and selective matrix metalloproteinase MMP-2 inhibitor (IC50=12 nM). ARP-100 interacts with S1＇ pocket of MMP-2 and shows anti-invasive properties in an in vitro model of invasion on matrigel. ARP-100 shows the less inhibitory activity towards MMP-1 (>50 μM), MMP-3 (4.5 μM), MMP-7 (>50 μM), and MMP-9 (0.2 μM). | ||
| M30642 | 1,8-Dihydroxy-4,5-dinitroanthraquinone | Anti-infection |
| ARDP0006; DHDNE | ||
| 1,8-Dihydroxy-4,5-dinitroanthraquinone (ARDP0006; DHDNE) is a potent inhibitor of serine proteinase NS2B/3, the dengue viral protein. 1,8-Dihydroxy-4,5-dinitroanthraquinone has intermolecular proteinase activity and viral inhibition ability with IC50s of 432 μM and 4.2 μM, respectively. Meanwhile 1,8-Dihydroxy-4,5-dinitroanthraquinone inhibits NS2B/3 cleavage in BHK-21 cells at a dose ranging from 4.2 μM to 432 μM. | ||
| M31128 | Recombinant Mouse MMP-2 Protein (HEK293, N-His) | Enzymes & Regulators |
| Matrix Metalloproteinase-2 | ||
| Matrix Metalloproteinase-2 (MMP-2) is an enzyme that plays a pivotal role in cell migration during physiological and pathological processes. The recombinant mouse MMP-2 consists 273 amino acids and predicts a molecular mass of 30.9 kDa. | ||
| M40618 | MIV-711 | Cathepsin |
| MIV-711 is a potent, selective tissue proteinase K (CTSK) inhibitor for osteoarthritis (OA)-related studies. | ||
| M40914 | Rivulariapeptolides 1155 | Serine/Threonine Protease |
| Rivulariapeptolides 1155 is a potent serine protease inhibitor with IC50 values of 41.84 nM, 4.94 nM, and 56.54 nM for chymotrypsin, elastase, and proteinase K, respectively. | ||
| M40915 | Rivulariapeptolides 988 | Serine/Threonine Protease |
| Rivulariapeptolides 988 is a potent and selective serine protease inhibitor with IC50 values of 95.46 nM, 15.29 nM and 85.50 nM for tryptic coagulase, elastase and proteinase K, respectively. | ||
| M40916 | Rivulariapeptolides 1185 | Serine/Threonine Protease |
| Rivulariapeptolides 1185 is a potent and selective serine protease inhibitor with IC50 values of 13.17 nM, 23.59 nM, and 55.26 nM for tryptic coagulase, elastase, and proteinase K, respectively. | ||
| M40917 | Rivulariapeptolides 1121 | Serine/Threonine Protease |
| Rivulariapeptolides 1121 is a potent and selective serine protease inhibitor with IC50 values of 35.52 nM, 13.24 nM, and 48.05 nM for tryptic coagulase, elastase, and proteinase K, respectively. | ||
| M43971 | Recombinant Human MMP12 Protein (E. coli) | Enzymes & Regulators |
| Matrix metalloproteinase-12 | ||
| Matrix metalloproteinase-12 (MMP12) is a macrophage-secreted elastase that is highly induced in the liver and lung in response to S. mansoni eggs and contains four hemopexin-like domains. MMP12 is a proteolytic enzyme responsible for the cleavage of plasminogen to angiotensin, which has an angiostatic effect. | ||
| M44768 | L-Rhamnose | Metabolite/Endogenous Metabolite |
| alpha-L-Rhamnose; Rhamnopyranose | ||
| L-Rhamnose (alpha-L-Rhamnose) is a monosaccharide found in plants and bacteria. L-Rhamnose can inhibit levels of pro-inflammatory interleukin and matrix metalloproteinases (MMPs) in skin aging models, showing anti-aging effects. Rhamnose can promote the phosphorylation levels of PKA substrates and HSL in SVF-derived adipocytes, stimulating PKA signaling. | ||
| M49482 | Otaplimastat | MMP |
| SP-8203 | ||
| Otaplimastat is a matrix metalloproteinase (MMP) inhibitor that competitively blocks NMDA receptor-mediated excitotoxicity. In addition, Otaplimastat has antioxidant activity and may be used in studies related to cerebral ischemic injury. | ||
| M50844 | MeOSuc-AAPF-CMK | Others |
| MeOSuc-AAPF-CMK (MeOSuc-Ala-Ala-Pro-Phe-CH Cl) is a potent proteinase K inhibitor. | ||
| M52532 | Z-LLF-CHO | Proteasome |
| Z-LLF-CHO (Z-Leu-Leu-Phe-CHO) is a potent inhibitor of the chymotrypsin-like activity of the pituitary multicatalytic proteinase complex (Ki = 460 nM). | ||
| M54141 | PAR-4 Agonist Peptide, amide | PAR |
| PAR-4 Agonist Peptide, amide (PAR-4-AP; AY-NH2) is a proteinase-activated receptor-4 (PAR-4) agonist, which has no effect on either PAR-1 or PAR-2 and whose effects are blocked by a PAR-4 antagonist. | ||
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