About 10 results found for searched term "PPO-IN-3" (0.122 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M43112 | PPO-IN-3 | Others |
| PPO-IN-3 is a PPO inhibitor with an KI value of 0.67 nM. | ||
| M2895 | Nutlin-3b | Mdm2 |
| (+)-Nutlin-3 | ||
| Nutlin-3b is a p53/MDM2 antagonist or inhibitor with IC50 value of 13.6 μM, 150-fold less potent (+)-enantiomer of Nutlin-3 as in comparison with opposite enantiomer Nutlin-3a. | ||
| M3999 | Isorhamnetin | PI3K |
| 3'-Methylquercetin | ||
| Isorhamnetin (Iso) is a flavonoid compound extracted from the Chinese herb Hippophae rhamnoides L. Previous studies have revealed its anti-cancer, anti-inflammatory, and anti-oxidant activities. Isorhamnetin suppresses skin cancer through direct inhibition of MEK1 and PI3K. | ||
| M4591 | Sodium-Aescinate | NF-κB |
| Sodium Aescinate is a triterpenoid saponin from Aesculus hippocastanum seeds with anti-inflammatory and antioxidant activities. Sodium aescinate inhibits liver cancer growth by targeting the CARMA3/NF-κB pathway. | ||
| M9057 | XMU-MP-1 | Hippo (MST) |
| XMU-MP-1 is a potent and selective Hippo/ MST1/2 inhibitor with IC50 values of 71.1 ± 12.9 nM and 38.1 ± 6.9 nM, respectively. | ||
| M27803 | Leucettine L41 | CDK |
| Leucettine L41 is a potent inhibitor of dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A), DYRK2, CDC-like kinase 1 (CLK1), and CLK3 (IC50s = 0.04, 0.035, 0.015, and 4.5 µM, respectively). Leucettine L41 prevents lipid peroxidation and the accumulation of reactive oxygen species (ROS) induced by Aβ25-35 in the hippocampus in a mouse model of Alzheimer’s disease-like toxicity. Leucettine L41 also prevents memory deficits induced by Aβ25-35 in the same model. | ||
| M28442 | β-Amyloid (22-35) | Amyloid |
| Amyloid β-Protein (22-35) | ||
| β-Amyloid 22-35 (Amyloid β-Protein 22-35), the residues 22-35 fragment ofβ-amyloid protein, has a cytotoxic effect on cultured neurons from the rat hippocampus in serum-free medium. β-Amyloid 22-35 forms aggregates and typical amyloid fibrils resembling those of the β-amyloid protein in neutral buffer solution). | ||
| M29222 | Yhhu-3792 | Notch |
| Yhhu-3792 enhances the self-renewal capability of neural stem cells (NSCs). Yhhu-3792 activates Notch signaling pathway and promotes the expression of Hes3 and Hes5. Yhhu-3792 expands the NSCs pool and promotes endogenous neurogenesis in the hippocampal dentate gyrus (DG) in mouse. Yhhu-3792 increases the spatial and episodic memory abilities of mice. Yhhu-3792 has the potential for the research of impairment of learning and memory associated DG dysfunction. | ||
| M53021 | Galanin (1-16), mouse, porcine, rat | Neuropeptide Receptor |
| Galanin (1-16), mouse, porcine, rat is an agonist of the hippocampal galanin receptor, with a Kd of 3 nM. | ||
| M55555 | PI3K/Akt/CREB activator 1 | PI3K |
| compound AE-18 | ||
| PI3K/Akt/CREB activator 1 (compound AE-18) is a potent, orally active PI3K/Akt/CREB activator. PI3K/Akt/CREB activator 1 promotes neuronal proliferation, induced differentiation of Neuro-2a cells into a neuron-like morphology, and accelerated the establishment of axon-dendrite polarization of primary hippocampal neurons through upregulating brain-derived neurotrophic factor via the PI3K/Akt/CREB pathway. | ||
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