About 31 results found for searched term "PI-55" (0.158 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M8937 | CPI-455 | Histone demethylase |
| CPI-455 is a potent and selective inhibitor of KDM5 demethylases which reduces survival of cancer cells, with a half-maximal inhibitory concentration (IC50) of 10 ± 1 nM for full-length KDM5A in enzymatic assays. | ||
| M13504 | Epibrassinolide | Plant growth regulators |
| 24-Epibrassinolide; B1105; BP55 | ||
| Epibrassinolide (24-Epibrassinolide) is a ubiquitously occurring plant growth hormone which shows great potential to alleviate heavy metals and pesticide stress in plants. | ||
| M21718 | PI-55 | Parasite |
| PI55 | ||
| PI-55 is a specific cytokinin receptor inhibitor. PI-55 is structurally related to 6-benzylaminopurine (BAP) and was shown to inhibit competitively BAP binding on Arabidopsis-specific receptors CRE1/AHK4 and AHK3. | ||
| M43390 | IHMT-PI3K-455 | PI3K |
| IHMT-PI3K-455 is a potent, selective, orally active PI3Kγ/δ dual inhibitor with IC50s of 7.1 nM and 0.57 nM for PI3Kγ and PI3Kδ, respectively. | ||
| M2623 | Desvenlafaxine | 5-HT Receptor |
| O-Desmethylvenlafaxine | ||
| Desvenlafaxine is a serotonin (5-HT) and norepinephrine (NE) reuptake inhibitor with Ki of 40.2 nM and 558.4 nM, respectively. | ||
| M2624 | Desvenlafaxine Succinate | 5-HT Receptor |
| O-Desmethylvenlafaxine succinate hydrate | ||
| Desvenlafaxine Succinate is a new serotonin (5-HT) transporter and norepinephrine (NE) transporter reuptake inhibitor with Ki of 40.2 nM and 558.4 nM respectively. | ||
| M3194 | Nocodazole | Src-bcr-Abl |
| Oncodazole；R17934 | ||
| Nocodazole is a rapidly-reversible inhibitor of microtubule polymerization, also inhibits Abl, Abl(E255K) and Abl(T315I) with IC50 of 0.21 μM, 0.53 μM and 0.64 μM, respectively. | ||
| M3751 | Losmapimod | p38 MAPK |
| GW-856553X; GSK-AHAB; SB856553 | ||
| Losmapimod (GW856553) is a selective, potent, and orally active p38 MAPK inhibitor with pKi of 8.1 and 7.6 for p38α and p38β, respectively. | ||
| M3768 | Ixabepilone | Microtubule |
| Ixempra, BMS-247550, NSC 710428 | ||
| Ixabepilone (BMS 247550) is an epothilone B analog and nontaxane microtubule-stabilizing compound with clinical activity in a range of solid tumors. | ||
| M4402 | Epiberberine | AChR/AChE |
| Epiberberine is a potent AChE and BChE inhibitor, and a non-competitive BACE1 inhibitor, with IC50s of 1.07, 6.03 and 8.55 μM, respectively. Epiberberine is also a potent inhibitor against both ureases with IC50 values of 3.0±0.01μM for HPU (ureases from Helicobacter pylori) and 2.3±0.01μM for JBU (ureases from jack bean). | ||
| M5290 | (±)-SLV-319 | Cannabinoid |
| (±)-Ibipinibant; BMS-646256 | ||
| (±)-SLV319 (Ibipinabant) is a potent and selective CB1 receptor antagonist (Ki = 7.8 nM). Exhibits 1000-fold selectivity for CB1 over CB2 receptors. Inhibits CP 55,940-induced hypotension and WIN 55,212-2-induced hypothermia in vivo. | ||
| M8723 | PBOX-15 | Others |
| PBOX-15 belongs to a group of tubulin-targeting pyrrolo-1,5-benzoxazepine (PBOX) compounds that potently induce apoptosis in a wide spectrum of cancer cells, including those originating from the four main types of leukemia and those exhibiting multi-drug resistance (IC50 = 155 nM/HL60-MDR1, 252 nM/HL60-ABCG2, 210 nM/HL60). | ||
| M13950 | Quinpirole Hydrochloride | Dopamine Receptor |
| (-)-LY 171555 | ||
| Quinpirole Hydrochloride ((-)-LY 171555) is a high-affinity agonist of dopamine D2/D3 receptor. | ||
| M14547 | Epiberberine chloride | AChR/AChE |
| Epiberberine chloride is an alkaloid isolated from Coptis chinensis, acts as a potent AChE and BChE inhibitor, and a non-competitive BACE1 inhibitor, with IC50s of 1.07, 6.03 and 8.55 μM, respectively. | ||
| M15059 | Psicofuranine | Antibiotic |
| Psicofuramine is a nucleoside antibiotic produced by the hygroscopic Streptomyces strain Bitter fungus. It has antifungal activity against Gram-positive bacteria and mycobacterium, and has antifungal activity against Walker cancer 256 in rats and Ca755 in mice. | ||
| M20713 | DMX-5084 | MAPKAPK2/MAP3K/MAP4K |
| DMX-5804 is a potent, orally active and selective inhibitor of Mitogen-activated protein kinase kinase kinase kinase-4 (MAP4K4) with IC50 of 3 nM for human MAP4K4. DMX-5804 is more potent on human MAP4K4 with pIC50 of 8.55 than MINK1/MAP4K6 and TNIK/MAP4K7 with pIC50 of 8.18 and 7.96, respectively. | ||
| M20834 | Pizuglanstat (TAS-205) | Others |
| Pizuglanstat (TAS-205) is a highly selective hematopoietic prostaglandin D synthase (HPGDS) inhibitor with an IC50 of 55.8 nM. | ||
| M20984 | Varenicline dihydrochloride | AChR/AChE |
| Chantix, Champix | ||
| Varenicline (CP 526555, Chantix, Champix) dihydrochloride is a potent, partial agonist of α4β2 nicotinic acetylcholine receptor (nAChR) and α3β4 nAChR with EC50 of 2.3 μM and 55 μM, respectively. Varenicline dihydrochloride is a potent, full agonist of α7 nAChRs with EC50 of 18 μM. Varenicline is a prescription medication used for smoking cessation. | ||
| M21215 | CP-628006 | CFTR |
| CP-628006 is a CFTR small molecule enhancer that enhances CFTR function in human bronchial epithelial (hBE) cells and restores ATP-dependent gated channels in cystic fibrosis mutant G551D-CFTR. It can be used in cystic fibrosis (CF) related studies. | ||
| M21290 | BMS-986144 | HCV Protease |
| BMS-986144 is a third generation pan-genotypic NS3/4A protease inhibitor.BMS-986144 inhibits GT-1a, GT-1b, GT-2a, GT-3a, 1a R155X, 1b D168V replicon with EC50 values of 2.3, 0.7, 1.0, 12, 8.0, 5.8 nM, respectively.BMS-986144 has the potential to study HCV infection. | ||
| M28241 | BRD5529 | E1/E2/E3 Enzyme |
| BRD5529 is an effective dose-dependent CARD9-TRIM62 protein–protein interaction (PPI) inhibitor with an IC50 value of 8.6 μM. BRD5529 has potency and complete inhibition of CARD9 ubiquitinylation in vitro, also has favorable solubility. BRD5529 can be used for the research of inflammatory bowel disease (IBD) such as Crohn’s disease (CD) and ulcerative colitis (UC). | ||
| M28711 | CH1055 | Fluorescent Dye |
| CH1055 is a NIR-II fluorophore based on a synthetic 970-Da organic molecule. CH1055 is a rapidly excreted dye (∼90% excreted through the kidneys within 24 h). CH1055 also allows targeted molecular imaging of tumors in vivo when conjugated with anti-EGFR Affibody. | ||
| M29386 | CCT367766 | PROTAC |
| CCT367766 is a potent and the third generation heterobifunctional and Cereblon-based pirin targeting protein degradation probe (PDP, or PROTAC), depletes pirin protein expression at low concentration. CCT367766 exhibits a moderate affinity for the CRBN-DDB1 complex with an IC50 value of 490 nM. CCT367766 reveals a good affinity for the recombinant pirin and CRBN with Kd values of 55 nM and 120 nM, respectively. CCT367766 provides a potential chemical tool to study a largely unexplored protein. | ||
| M29961 | TGX-155 | PI3K |
| AZ12649385 | ||
| TGX-155 (AZ12649385) is a selective inhibitor of PI3Kβ. TGX-155 has potential applications in antithrombotic therapy. | ||
| M31067 | CH1055 triethylamine | Fluorescent Dye |
| CH1055 triethylamine is a NIR-II fluorophore based on a synthetic 970-Da organic molecule. CH1055 triethylamine is a rapidly excreted dye (∼90% excreted through the kidneys within 24 h). CH1055 triethylamine also allows targeted molecular imaging of tumors in vivo when conjugated with anti-EGFR Affibody. | ||
| M31074 | CCT367766 formic | PROTAC |
| CCT367766 formic is a potent and the third generation heterobifunctional and Cereblon-based pirin targeting protein degradation probe (PDP, or PROTAC), depletes pirin protein expression at low concentration. CCT367766 formic exhibits a moderate affinity for the CRBN-DDB1 complex with an IC50 value of 490 nM. CCT367766 formic reveals a good affinity for the recombinant pirin and CRBN with Kd values of 55 nM and 120 nM, respectively. | ||
| M38804 | 4-Methoxycinnamaldehyde | RSV |
| 4-Methoxycinnamaldehyde (p-Methoxycinnamaldehyde) is an active constituent of Agastache rugosa, exhibits cytoprotective activity against respiratory syncytial virus (RSV) in human larynx carcinoma cell line. 4-Methoxycinnamaldehyde effectively inhibits cytopathic effect of RSV with an estimated IC50 of 0.055 ug/mL. | ||
| M39053 | 8,3′,4′-Trihydroxyflavone-7-O-β-D-glucopyranoside | Others |
| 8,3′,4′-Trihydroxyflavone-7-O-β-D-glucopyranoside (Compound 3) is natural product that can be isolated from Bidens bipinnata. 8,3′,4′-Trihydroxyflavone-7-O-β-D-glucopyranoside shows 22% inhibition against α-amylase at 0.556 mg/mL. | ||
| M42346 | KLK7/ELA2-IN-1 | Elastase |
| KLK7/ELA2-IN-1 is a potent kallikrein-related peptidase 7 (KLK7) and epidermal elastase 2 (ELA2) inhibitor with IC50s of 6 nM and 55 nM, respectively. | ||
| M43372 | PI3K-IN-48 | Akt |
| PI3K-IN-48 is a PI3K inhibitor with IC50 value of 1.55 ± 0.18 μM for A549 cells. | ||
| M43388 | PI3Kγ inhibitor 7 | PI3K |
| PI3Kγ inhibitor 7 is a potent and orally active PI3Kγ inhibitor with IC50 values of 4768, 878.1, 3.42, 355.2 nM for PI3Kα, PI3Kβ, PI3Kγ, PI3Kδ, respectively. | ||
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