PDE5-IN-10 - Search Results | AbMole BioScience

About 5 results found for searched term "PDE5-IN-10" (0.13 seconds)

Cat.No.	Name	Target
M42563	PDE5-IN-10	PDE
	PDE5-IN-10 is a potent PDE5 inhibitor with an IC50 of 20 nM.
M2030	Apremilast	PDE
	CC-10004
	Apremilast is a novel, orally available small molecule inhibitor of PDE4 with IC50 of 74 nM. Apremilast inhibits TNF-α release by lipopolysaccharide (LPS) with an IC50 of 104 nM.
M14500	Osoresnontrine	PDE
	BI-409306
	Osoresnontrine (BI-409306) is a potent and selective PDE9A inhibitor, with an IC₅₀ of 52 nM, and shows weak activity against other PDEs, such as PDE1A (IC₅₀, 1.4 µM), PDE1C (IC₅₀, 1.0 µM), PDE2A, PDE3A, PDE4B, PDE5A, PDE6AB, PDE7A, and PDE10A (IC₅₀ all > 10 μM); Osoresnontrine can be used in the research of memory enhancement in CNS disorders.
M28193	JNJ-42314415	PDE
	JNJ-42314415 is a centrally active phosphodiesterase 10A (PDE10A) inhibitor, with Ki values of 35 nM and 64 nM for human recombinant PDE10A and rPDE10A, respectively.
M29544	TMX-4100	PDE
	TMX-4100 is a selective phosphodiesterase 6D (PDE6D) degrader. TMX-4100 shows a high degradation preference for PDE6D with the DC50 values less than 200 nM in MOLT4, Jurkat, and MM.1S cells. TMX-4100 can be used for the research of multiple myeloma.