About 6 results found for searched term "PARP-1/2-IN-2" (0.124 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M41360 | PARP-1/2-IN-2 | PARP |
| PARP-1/2-IN-2-IN-1 is a PARP1/2/CDK12 inhibitor (IC50: 34, 30 and 285 nM respectively). | ||
| M1732 | Talazoparib (BMN-673) | PARP |
| BMN673; LT-673 | ||
| Talazoparib (BMN-673) is a highly potent, orally active PARP1/2 inhibitor.Talazoparib inhibits PARP1 and PARP2 enzyme activity with Kis of 1.2 nM and 0.87 nM, respectively. Talazoparib has antitumor activity. | ||
| M2215 | Niraparib (MK-4827) | PARP |
| MK-4827 | ||
| MK-4827 (Niraparib) is a selective PARP1/2 inhibitor with an IC50 value of 3.8 nM/2.1 nM that increases the formation of PARP-DNA complexes through inhibition of PARPase activity, leading to DNA damage, apoptosis, PARP-1-dependent cell death (parthanatos) and cell death. Strong effector activity when acting on cancer cells harboring mutant BRCA-1 and BRCA-2. It is more than 330-fold more selective than PARP3, V-PARP and Tank1. | ||
| M5267 | E7449 | PARP |
| Stenoparib; 2X-121; MGI25036 | ||
| E7449 is an orally bioavailable, brain penetrable, small molecule dual inhibitor of PARP1/2 that also inhibits PARP5a/5b, otherwise known as tankyrase1 and 2 (TNKS1/2), important regulators of canonical Wnt/β-catenin signaling. It has IC50 values of 1.0 and 1.2 nM for PARP1 and 2, respectively. | ||
| M25444 | Senaparib | PARP |
| IMP4297; JS109 | ||
| Senaparib (IMP4297) is a highly potent, selective and orally active PARP1/2 inhibitor. Senaparib (IMP4297) exhibits strong antitumor activity. | ||
| M28932 | AZ9482 | PARP |
| AZ9482 is a triple PARP1/2/6 inhibitor, with IC50 values of 1 nM, 1 nM and 640 nM for PARP1, PARP2 and PARP6, respectively. | ||
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