About 17 results found for searched term "Orexin 2 Receptor Agonist" (0.128 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M9855 | Orexin 2 Receptor Agonist | OX Receptor |
| ABM-565520 | ||
| Orexin 2 Receptor Agonist (ABM-565520) is a potent and selective Orexin2 receptor agonist with EC50 value of 23 nM. | ||
| M3710 | MK-3697 | OX Receptor |
| MK-3697 is an isonicotinamide small molecule, acting as a potent and selective Orexin 2 receptor antagonist with Ki = 0.95 nM. | ||
| M7396 | TCS-OX2-29 | OX Receptor |
| TCS-OX2-29 is a potent, high affinities and selective orexin-2 receptor (OX2R) antagonist with an IC50 value of 40 nM and a pKI value of 7.5. TCS-OX2-29 displays ~250-fold selectivity for OX2 over OX1. | ||
| M8523 | ACT-462206 | Others |
| ACT-462206 is a orally active, brain penetrant, potent and selective dual orexin1/2 receptor antagonist (DORA). | ||
| M8997 | MK-1064 | OX Receptor |
| MK-1064 is a potent, selective and orally active Orexin OX2 Receptor Antagonist for the research of insomnia. | ||
| M14034 | Almorexant hydrochloride | OX Receptor |
| ACT-078573 hydrochloride | ||
| Almorexant hydrochloride (ACT 078573 hydrochloride) is a potent and competitive dual orexin 1 receptor (OX1)/orexin 2 receptor (OX2) antagonist with Ki values of 1.3 and 0.17 nM, respectively. | ||
| M14035 | EMPA | OX Receptor |
| EMPA is a high-affinity, reversible and selective orexin OX2 receptor antagonist. [3H]EMPA binds to human and rat OX2-HEK293 membranes with KD values of 1.1 and 1.4 nM respectively. | ||
| M14037 | Orexin receptor antagonist 3 | OX Receptor |
| Orexin receptor antagonist 3 (example 216) is an orexin receptor antagonist. | ||
| M14038 | Seltorexant | OX Receptor |
| JNJ-42847922 | ||
| Seltorexant (JNJ-42847922) is an orally active, high-affinity, and selective orexin-2 receptor (OX2R) antagonist (pKi values of 8.0 and 8.1 for human and rat OX2R). | ||
| M25479 | [Ala11,D-Leu15]-Orexin B (human) acetate | OX Receptor |
| [Ala11,D-Leu15]-Orexin B (human) acetate is a potent and selective orexin-2 receptor (OX2) agonist. [Ala11,D-Leu15]-Orexin B (human) acetate shows a 400-fold selectivity for the OX2 (EC50=0.13 nM) over OX1 (EC50=52 nM). | ||
| M28891 | YNT-185 | OX Receptor |
| YNT-185 is a nonpeptide, selective orexin type-2 receptor (OX2R) agonist, with EC50s of 0.028 and 2.75 μM for OX2R and OX1R, respectively. YNT-185 ameliorates narcolepsy-cataplexy symptoms in mouse models. | ||
| M28892 | YNT-185 dihydrochloride | OX Receptor |
| YNT-185 dihydrochloride is a nonpeptide, selective orexin type-2 receptor (OX2R) agonist, with EC50s of 0.028 and 2.75 μM for OX2R and OX1R, respectively. YNT-185 dihydrochloride ameliorates narcolepsy-cataplexy symptoms in mouse models. | ||
| M29476 | Suntinorexton | OX Receptor |
| Suntinorexton, a heterocyclic compound, is an orexin type 2 receptor agonist. | ||
| M29477 | Firazorexton | OX Receptor |
| TAK-994 | ||
| Firazorexton is a potent orexin type 2 receptor (OX2R) agonist. | ||
| M40751 | Nemorexant hydrochloride | OX Receptor |
| Nemorexant hydrochloride is an orally active dual orexin type 1 and type 2 (OX1 and OX2) receptor antagonist (DORA) as well as an inhibitor of BCRP, with an IC50 value of 3.0 μM when acting on BCRP, and can be used in studies related to insomnia. | ||
| M41896 | Firazorexton hydrate | OX Receptor |
| Firazorexton hydrate (TAK-994) is a potent, brain-penetrant, and orally active orexin type 2 receptor (OX2R) agonist (EC50: 19 nM). | ||
| M54494 | [Ala11, D-Leu15]-Orexin B(human) | OX Receptor |
| [Ala11,D-Leu15]-Orexin B(human) is a potent and selective orexin-2 receptor (OX2) agonist. | ||
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