About 3 results found for searched term "NS-398" (0.148 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M7051 | NS-398 | COX |
| NS398 | ||
| NS-398 is a cyclooxygenase-2 (COX-2) inhibitor, selectively inhibits prostaglandin G/H synthase 2/cyclooxygenase 2 (COX-2) activity, with an IC50 of 3.8 μM, and has no effect on COX-1 at 100 μM. NS-398 is a non-steroidal an-inflammatory agent with analgesic and antipyretic effects. | ||
| M14045 | Selexipag | Prostaglandin Receptor |
| NS-304; ACT-293987 | ||
| Selexipag (NS-304) is the methanesulfonamide precursor compound of ACT-333679 and an orally effective prostacyclin (PGI2) receptor agonist. It can be used in studies related to pulmonary arterial hypertension. | ||
| M27813 | CM398 | Sigma Receptor |
| CM398 is a highly selective, orally active sigma-2 receptor ligand (Ki=0.43 nM), with high sigma-1/sigma-2 selectivity rato (1000-fold). CM398 shows notable affinity for dopamine (Ki=32.90 nM) and serotonin transporters (Ki=244.2 nM). CM398 shows promising anti-inflammatory analgesic effects in the formalin model of inflammatory pain in mice. | ||
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