About 30 results found for searched term "NO Synthase" (0.107 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M25538 | Recombinant Human SEPHS1 (HEK293, C-6His) | Cytokines and Growth Factors |
| Selenide; Selenophosphate synthase 1 | ||
| Selenophosphate synthetase 1 (SEPHS1) belongs to the selenophosphate synthase 1 family, Class II subfamily. SEPHS1 can be activated by phosphate ions and by potassium ions. | ||
| M2604 | C75 | FAS |
| C75 is a novel, potent synthetic inhibitor of fatty acid synthase (FAS). C75 inhibits prostate cancer cells PC3 with an IC50 of 35 μM. C75 is a potent CPT1A activator. | ||
| M4003 | Isoquercitrin | Wnt/beta-catenin |
| Quercetin 3-glucoside; IQ | ||
| Isoquercetin (Quercetin 3-glucoside) is a naturally occurring polyphenol that has antioxidant, anti-proliferative, and anti-inflammatory properties. Isoquercetin alleviates ethanol-induced hepatotoxicity, oxidative stress, and inflammatory responses via the Nrf2/ARE antioxidant signaling pathway. Isoquercetin regulates the expression of nitric oxide synthase 2 (NO2) via modulating the nuclear factor-κB (NF-κB) transcription regulation system. | ||
| M4861 | Anidulafungin | Anti-infection |
| LY303366 | ||
| Anidulafungin (LY303366), a derivative of echinodermatin that inhibits glucan synthase activity and is used as an antifungal compound. | ||
| M5408 | Aminoguanidine hydrochloride | NO Synthase |
| Pimagedine; GER-11; Guanyl hydrazine; Hydrazinecarboximidamide | ||
| Aminoguanidine hydrochloride is a diamine oxidase and nitric oxide synthase inhibitor. It acts to reduce levels of advanced glycation end products (AGEs) through interacting with 3-deoxyglucosone. | ||
| M6132 | ECBN HCL | Others |
| ECBN obtained by the fermentation of Aspergillus nidulans and Aspergillus rugulosus, is known as one of the natural cyclic hexapeptides that have a linoleoyl side chain, which inhibits a crucial enzyme in fungal cell wall biosynthesis, β-(1,3)-d-glucan synthase. | ||
| M6170 | Bedaquiline fumarate | Antibiotic |
| R403323; TMC207 fumarate; R207910 fumarate | ||
| Bedaquiline fumarate, a diarylquinoline antibiotic that targets ATP synthase, is effective for the treatment of Mycobacterium tuberculosis infections. | ||
| M6291 | 5-Iodotubercidin | PKA |
| NSC 113939, 5-ITu | ||
| 5-IOdotubercidin (NSC 113939), an ATP analogue, is a potent inhibitor of adenosine kinase with an IC50 value of 26 nM. 5-IOdotubercidin (NSC 113939) initiates glycogen synthesis in isolated hepatocytes by activating phosphorylase and glycogen synthase. 5-IOdotubercidin (NSC 113939) also inhibits CK1, insulin receptor tyrosine kinase, phosphorylase kinase, PKA, CK2, PKC, and Haspin inhibitors. | ||
| M6415 | Agmatine sulfate | Imidazoline Receptor |
| Agmatine sulfate is an endogenous agonist at imidazoline receptor and a NO synthase inhibitor. Agmatine sulfate exerts modulatory action at multiple molecular targets, such as neurotransmitter systems, ion channels and nitric oxide synthesis. | ||
| M7431 | TRIM | NO Synthase |
| TRIM is a a potent inhibitor of neuronal and inducible NO synthases, with much lower affinity for the endothelial isoform (displays IC50 values of 28.2, 27.0 and 1057.5 μM respectively). | ||
| M8896 | MDK36122 | PGE synthase |
| H-PGDS Inhibitor I | ||
| MDK36122, also known as H-PGDS Inhibitor I, is a Prostaglandin D Synthase (hematopoietic-type) Inhibitor with an IC50 Value of 0.7 nM. | ||
| M9126 | Ac-CoA Synthase Inhibitor 1 | Anti-infection |
| Ac-CoA Synthase Inhibitor I | ||
| Ac-CoA Synthase Inhibitor 1 (also known as ACSS2 Inhibitor), an anti-virus agent, is a Ac-CoA Synthase Inhibitor. | ||
| M9179 | Nolatrexed 2HCl | DNA/RNA Synthesis |
| AG-337; NOL | ||
| Nolatrexed 2HCl, also known as AG337, is a thymidylate synthase inhibitor. | ||
| M9186 | Bedaquiline | Antibiotic |
| R403323; TMC207; R207910 | ||
| Bedaquiline (TMC207) is a diarylquinoline antibiotic that targets ATP synthase, can be used for the research of Mycobacterium tuberculosis infections. | ||
| M9447 | RU320521 | Others |
| RU521; RU.521 | ||
| RU320521 (also known as RU521; RU.521) is a potent and selective inhibitor of cyclic GMP-AMP synthase (cGAS), inhibiting cGAS-mediated interferon upregulation. | ||
| M10310 | Miglustat hydrochloride | Glucosylceramide Synthase |
| OGT 918 HCl; NB-DNJ HCl; Miglustat HCl | ||
| Miglustat hydrochloride also known as OGT 918 and NB-DNJ, inhibits glucosylceramide synthase, and is used primarily to treat Type I Gaucher disease (GD1). | ||
| M10390 | Aminooxy-acetic acid (AOA) | GABA Receptor |
| 2-(Aminooxy)acetic acid | ||
| Aminooxy-acetic acid (AOA) is a GABA transaminase (GABA-T) inhibitor (Ki = 9.16 μM) that induces GABA accumulation in the brain. It also inhibits cystathionine β synthase (CBS) and cystathionine γ lyase (CSE) with IC50 values of 8.5 and 1.1 μM, respectively. Aminooxyacetic acid (Carboxymethoxylamine) is a malate-aspartate shuttle (MAS) inhibitor. | ||
| M10446 | 1400W dihydrochloride | NO Synthase |
| N-(3-(AMinoMethyl)benzyl)acetaMidine Dihydrochloride | ||
| 1400W dihydrochloride is a potent and selective inhibitor of human inducible NO synthase with Ki values of 7 nM. 1400W inhibits iNOS induction in microglial cells, and reduces generation of NO, thereby mitigating oxidative stress and neuronal cell apoptosis in the rat cerebral cortex. | ||
| M10833 | Ibrexafungerp | Anti-infection |
| SCY-078; MK-3118 | ||
| Ibrexafungerp is a novel, orally available glucan synthase inhibitor with in vitro activity against many echinocandin-resistant Candida strains. | ||
| M10903 | Cucurbitadienol | Others |
| Cucurbitadienol has significant anti-inflammatory, anti-tumor effect, is also CucurbitacinBE compounds biosynthesis the key intermediate. Cucurbitadienol synthase, the first committed enzyme for cucurbitacin biosynthesis, is a distinct enzyme from cycloartenol synthase for phytosterol biosynthesis. CYP87D18 catalyzed the oxidation of cucurbitadienol at C-11 to produce 11-oxo cucurbitadienol and 11-hydroxy cucurbitadienol. | ||
| M14099 | L-NIL | NO Synthase |
| L-NIL is an inducible NO synthase inhibitor, with an IC50 of 3.3 μM for miNOS. | ||
| M14100 | L-NIO dihydrochloride | NO Synthase |
| L-NIO dihydrochloride is a potent, non-selective and NADPH-dependent nitric oxide synthase (NOS) inhibitor, with Kis of 1.7, 3.9, 3.9 μM for neuronal (nNOS), endothelial (eNOS), and inducible (iNOS), respectively. | ||
| M20756 | 2'-Deoxyuridine 5'-monophosphate disodium salt | Others |
| dUMP | ||
| 2'-Deoxyuridine 5'-monophosphate disodium salt (dUMP) is a substrate for thymidylate synthase and is converted to deoxythymidine monophosphate (dTMP). The inhibition of dUMP to dTMP at the methylation step is a key in controlling bacterial and eukaryotic cell growth. | ||
| M20781 | Bendazol | NO Synthase |
| 2-Benzylbenzimidazole, Dibazol, Dibazole, Bendazole, Tromasedan | ||
| Bendazol (2-Benzylbenzimidazole, Dibazol, Dibazole, Bendazole, Tromasedan) is a hypotensive drug that enhances NO synthase activity in renal glomeruli and collecting tubules. Bendazol inhibits the progression of form-deprivation myopia (FDM) and suppresses the upregulation of HIF-1α. | ||
| M21413 | Inflexuside B | NO Synthase |
| Inflexuside B, an abietane diterpenoid, can be isolated from the aerial parts of Isodon inflexus. Inflexuside B strongly inhibits lipopolysaccharide (LPS)-activated NO Synthase in RAW264.7 macrophages | ||
| M28899 | SMS1-IN-1 | Others |
| SMS1-IN-1, compound SAPA 1j, is a novel and the most potent sphingomyelin synthase 1 (SMS1) inhibitor with an IC50 value of 2.1 μM. SMS1-IN-1 has the potential for the treatment of atherosclerosis. | ||
| M29362 | 6-Biopterin | NO Synthase |
| L-Biopterin | ||
| 6-Biopterin (L-Biopterin), a pterin derivative, is a NO synthase cofactor. | ||
| M29870 | Asymmetric dimethylarginine | Metabolite/Endogenous Metabolite |
| Asymmetric dimethylarginine is an endogenous inhibitor of nitric oxide synthase (NOS), and functions as a marker of endothelial dysfunction in a number of pathological states. | ||
| M29968 | Caraphenol A | Others |
| Caraphenol A is a resveratrol trimer and is able to transiently reduce interferon-induced transmembrane (IFITM) protein expression. Caraphenol A safely enhances lentiviral vector gene delivery to hematopoietic stem and progenitor cells. Caraphenol A also inhibits human cystathionine β-synthase (hCBS) and human cystathionine γ- lyase (hCSE) with IC50s of 5.9 μM and 12.1 μM, respectively. | ||
| M29977 | Pemetrexed disodium heptahydrate | Antifolate |
| LY231514 disodium heptahydrate | ||
| Pemetrexed disodium heptahydrate is a novel antifolate, the Ki values of the pentaglutamate of LY231514 are 1.3, 7.2, and 65 nM for inhibits thymidylate synthase (TS), dihydrofolate reductase (DHFR), and glycinamide ribonucleotide formyltransferase (GARFT), respectively. | ||
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