About 2 results found for searched term "NK-252" (0.129 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M14595 | NK-252 | Keap1-Nrf2 |
| NK-252 is a potential Nrf2 activator, which exhibits a great Nrf2-activating potential. | ||
| M55253 | SL-279252 | PD-1/PD-L1 |
| PD1-Fc-OX40L | ||
| SL-279252 (PD1-Fc-OX40L) is a hexameric, bi-functional fusion protein with an ECD of PD-1 (70 pM affinity to PD-L1) linked to the ECD of OX40L (324 pM affinity for OX40) through an Fc linker. SL-279252 exhibited linear PK at doses up to 3.0 mg/kg, and a greater than proportional increase in AUC was observed at 6.0 mg/kg suggesting potential receptor saturation. The preliminary half-life is approximately 23 hours. | ||
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