About 1 result found for searched term "NIC-0102" (0.206 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M54581 | NIC-0102 | Proteasome |
| NIC-0102 is an orally potent proteasome inhibitor (pIC50=7.55) that specifically inhibits NLRP3 inflammasome activation.NIC-0102 showed potent anti-inflammatory effects in vivo in a DSS-induced ulcerative colitis model. In addition, NIC-0102 inhibited the production of pro-IL-1β. | ||
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