About 32 results found for searched term "NG25" (0.079 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M9342 | NG25 | MAPKAPK2/MAP3K/MAP4K |
| NG25 is a potent dual TAK1 and MAP4K2 inhibitor with IC50s of 149 nM and 21.7 nM, respectively. | ||
| M25429 | Rezafungin acetate | Anti-infection |
| Biafungin acetate; CD101 acetate; SP-3025 acetate | ||
| Rezafungin acetate is a novel echinocandin-based antifungal agent with potent antifungal activity against Candida, Aspergillus and Pneumocystis. | ||
| M51345 | Fibronectin Type III Connecting Segment Fragment 1-25 | Others |
| Fibronectin Type III Connecting Segment Fragment 1-25 is a peptide that is responsible for melanoma cell adhesion, and plays an important role in development of the peripheral nervous system in chicken. | ||
| M1854 | VX-770 (Ivacaftor) | CFTR |
| Ivacaftor | ||
| VX-770 (Ivacaftor) is a first-in-class potentiator of CFTR, which targeting G551D-CFTR and F508del-CFTR with EC50 of 100 nM and 25 nM, respectively. | ||
| M2085 | Tie2 kinase inhibitor | Others |
| Tie2 kinase inhibitor 1; compound 5 | ||
| Tie2 kinase inhibitor is a potent, reversible, and ATP-binding site-targeting Tie2 inhibitor with an IC50 of 250 nM. | ||
| M2225 | Thalidomide | Ligand for E3 Ligase |
| Thalomid | ||
| Thalidomide is a sedative and immunomodulator used to study the symptoms of many cancers, it has immunomodulatory, anti-inflammatory and anti-angiogenic cancer properties. Thalidomide inhibits cereblon (CRBN), a part of the cullin-4 E3 ubiquitin ligase complex CUL4-RBX1-DDB1, with a Kd of ∼250 nM. | ||
| M2361 | 4EGI-1 | Eukaryotic Initiation Factor |
| 4EGI-1 is a competitive eIF4E/eIF4G interaction inhibitor by binding to eIF4E with KD of 25 μM. | ||
| M2516 | Cholesterol | Estrogen Receptor |
| Cholesterol is a major sterol in mammals, accounting for 20-25% of the structural components of the plasma membrane, and plays an important role in characterizing membrane fluidity and permeability, as well as the function of transporter and signaling proteins. In addition, Cholesterol is an endogenous estrogen-related receptor alpha (ERRα) agonist. | ||
| M2972 | Q-VD-OPh | Caspase |
| QVD-OPH; Quinoline-Val-Asp-Difluorophenoxymethylketone | ||
| Q-VD-OPh is a potent, irreversible pan-caspase inhibitor with IC50 ranging from 25 to 400 nM for caspases 1, 3, 8, and 9, showing inhibitory effects on terminal caspase activation, substrate cleavage, and DNA ladder formation associated with apoptosis. | ||
| M9117 | W-54011 | Immunology/Inflammation |
| W-54011 HCl | ||
| W-54011 is a potent, specific, and orally active CD88 (C5a receptor) antagonist, which inhibits the binding of 125I-labeled C5a to human neutrophils with a Ki value of 2.2 nM. | ||
| M4356 | β-Mangostin | Antibiotic |
| Beta-mangostin (β -mangostin) is a compound of oxyxanthone present in Cratoxylum arborescens, which has antibacterial and antimalarial activities. The MIC value of beta-mangostin against M. tuberculosis was 6.25 μg/mL. Beta-mangostin showed anti-malarial activity in vitro with IC50 value of 3.00 μg/mL against P. falciparum. Beta-mangostin has strong anticancer activity against various cancers, such as hepatocellular carcinoma and leukemia. | ||
| M4578 | Oridonin | NLR |
| Isodonol；NSC-250682 | ||
| Oridonin is a covalent NLRP3 inhibitor with strong anti-inflammasome activity. Oridonin (NSC-250682) also acts as an inhibitor of AKT, with IC50 values of 8.4 and 8.9 μM for AKT1 and AKT2, respectively. | ||
| M5135 | Ro-46-2005 | Endothelin Receptor |
| Ro 46-2005 is a novel synthetic non-peptide endothelin receptor antagonist, inhibits the specific binding of 125I-ET-1 to human vascular smooth muscle cells (ETA receptor) with IC50 of 220 nM. | ||
| M7790 | Emodin | Casein Kinase |
| Frangula emodin | ||
| Emodin is an anti-SARS-CoV compound that blocks the interaction between the SARS-coronavirus spike protein and angiotensin converting enzyme 2 (ACE2). Emodin inhibited casein kinase 2 (CK2) and 11β-HSD1. Emodin can also induce necrotic apoptosis of glioma U251 cells and inhibit U251 cell proliferation by targeting the TNF/RIPK1/RIPK3 signaling pathway. | ||
| M8090 | PF-04965842 | JAK |
| Abrocitinib | ||
| Abrocitinib is an orally active and selective JAK1 inhibitor with an IC50 value of 29 nM. Abrocitinib reversibly inhibits JAK1 kinase by blocking its ATP-binding site. Abrocitinib (PF-04965842) inhibited TYK2 activity (IC50, 1.253 μM) and phosphorylation of STAT1, STAT3, and STAT5 after stimulation. It can be used in the study of autoimmune diseases. | ||
| M8723 | PBOX-15 | Others |
| PBOX-15 belongs to a group of tubulin-targeting pyrrolo-1,5-benzoxazepine (PBOX) compounds that potently induce apoptosis in a wide spectrum of cancer cells, including those originating from the four main types of leukemia and those exhibiting multi-drug resistance (IC50 = 155 nM/HL60-MDR1, 252 nM/HL60-ABCG2, 210 nM/HL60). | ||
| M8968 | FPS-ZM1 | Amyloid |
| FPS-ZM1 is a high-affinity RAGE-specific blocker that inhibits amyloid-β binding to RAGE with a Ki of 25 nM. | ||
| M10385 | LC-2 | PROTAC |
| LC-2 is a potent first-in-class PROTAC capable of degrading endogenous KRAS G12C, with DC50s between 0.25 and 0.76 μM. | ||
| M10515 | JNJ-10229570 | Melanocortin Receptor |
| UNII-N9IX402L35; JNJ10229570 | ||
| JNJ-10229570 (UNII-N9IX402L35) is is a novel MC1R and MC5R antagonist, which inhibits the binding of 125I-NDP-α-MSH to cells expressing human MC1R and MC5R with IC50 values of 270 nM and 200 nM, respectively. | ||
| M15052 | Recombinant Human 4-1BB Ligand/TNFSF (E.coli,C-6His) | Recombinant Proteins |
| Tumor necrosis factor ligand superfamily member 9; | ||
| The recombinant human 4-1BB ligand was produced by the escherichia coli expression system, and the target gene encoding ARG71-GLU254 was expressed at the C-terminal as 6His marker. Accession # : P41273. | ||
| M10709 | TAS0728 | EGFR/HER2 |
| TAS0728 is an effective, selective, oral, irreversible, covalently bound HER2 inhibitor covalently bound to the C805 site of HER2, inhibiting its activity.IC50 The value is 13 nM. TAS0728 to BMX, HER4, BLK, EGFR, JAK3, SLK, LOK and HUMAN HER2 IC50 The values are 4.9, 8.5, 31, 65, 33, 25, 86, and 36 nM, respectively. TAS0728 simultaneously inhibits phosphorylation of HER2, HER3 and its downstream effector proteins. Has antitumor activity. | ||
| M10922 | Recombinant Mouse TGF-beta 1 Protein (Human Cells) | Recombinant Proteins |
| TGF-β1, Mouse | ||
| Recombinant Mouse TGF-beta 1 Protein is a multifunctional cytokine that controls many biological processes including immunity, differentiation, tumor suppression, tumor metastasis, aging, migration, wound healing, apoptosis, cell division, adipogenesis, and osteogenesis. ED50 is 5-25 pg/ml | ||
| M10956 | PAT-1251 | Monoamine Oxidase |
| PAT-1251 is a potent, selective, orally lysanyl oxidase-like protein 2 (LOXL2) inhibitor of hLOXL2 and hLOXL3 IC50 The values were 0.71 and 1.17 μM, respectively, and the inhibition of LOXL2 in mice, rats, and dogs was strong.IC50 Values are 0.10, 0.12, and 0.16 μM, respectively; PAT-1251 can be used for studies of a variety of fibrous diseases. | ||
| M11039 | Pyrazoloacridine | Topoisomerase |
| NSC 366140 | ||
| Pyrazoloacridine (NSC 366140) has anticancer activity, inhibiting the activity of topoisomerases 1 and 2 (topoisomerases 1 and 2). Pyrazoloacridine (NSC 366140) on K562 in myeloid leukemia cells IC50 The value is 1.25 μM (24 h). | ||
| M11391 | Recombinant Human 4-1BB Ligand Protein (HEK293) | Recombinant Proteins |
| Recombinant Human 4-1BB Ligand Protein (HEK293) Protein sequence: DNA sequence encoding human 4-1BB Ligand (NP_003802.1) expressed with Fc tag at c-terminal Bioactivity: Fixed human 4-1BB (His tag) at a concentration of 1ug/mL (100 μL/ well) can bind 4-1BB ligands (Fc tag) in a linear range of 1.25-20ug/mL | ||
| M11465 | trans-Cinnamic acid | Antibiotic |
| trans-Cinnamic acid； Phenylacrylic acid, Cinnamylic acid | ||
| Trans-cinnamic acid was A fungicide with A minimum inhibitory concentration (MIC) of 250 μg/mL against A. sobria (SY-AS1). | ||
| M11515 | Hoechst 34580 | Fluorescent Dye |
| HOE 34580 | ||
| Hoechst 34580 (HOE 34580) is related to important small furrow binding dsDNA selective dyes Hoechst 33258 and Hoechst 33342, with a maximum excitation/emission wavelength of 392nm/440 nm (after binding to DNA), emitting blue fluorescence. For observation of nuclei, nucleic acids, stored at -25°C, away from light. | ||
| M11523 | Rhodamine 6G | Fluorescent Dye |
| Basic Red 1；Rhodamine 590；R6G | ||
| Rhodamine 6G (Rhodamine 6G) is a fluorescent tracer that can bind to mitochondria, with a maximum excitation/emission wavelength of 525nm/550nm. It emits orange-red fluorescence and should be stored away from light. | ||
| M13447 | Recombinant Human IGF-II (E. coli) | Recombinant Proteins |
| Insulin-like Growth Factor-II; Somatamedin A | ||
| Insulin-like Growth Factor II (IGF-II) is a 7 kDa single chain polypeptide with high homology to insulin. Protein structure：Expressed with an N-terminal Met. Igf-ii (ALA25-GLU91) , Accession # P01344-1. | ||
| M13788 | Hoechst 33258 analog 6 | Fluorescent Dye |
| Hoechst 33258 analog 6 is a anglog of Hoechst stains(Hoechst 33258), which are part of a family of blue fluorescent dyes used to stain DNA. | ||
| M13908 | AVE 0991 sodium salt | Angiotensin Receptor |
| AVE 0991 sodium salt is a nonpeptide and orally active Ang-(1-7) receptor Mas agonist. AVE 0991 competes for high-affinity binding of [125I]-Ang-(1-7) to bovine aortic endothelial cell membranes with IC50 of 21 nM. | ||
| M14427 | BMS-309403 sodium | Others |
| BMS-309403 sodium is a potent, orally active, and selective adipocyte fatty acid binding protein (also known as FABP4, aP2) inhibitor, with Kis of <2, 250, and 350 nM for FABP4, FABP3, and FABP5, respectively. | ||
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