About 4 results found for searched term "Melatonin-d4" (0.149 seconds)
Cat.No. | Name | Target |
---|---|---|
M55436 | Melatonin-d4 | Melatonin Receptor |
Melatonin-d4 | ||
M2230 | Agomelatine | Melatonin Receptor |
Valdoxan; Melitor; S-20098 | ||
Agomelatine is a metabolically stable analog of melatonin that displays agonist activity for MT1 and MT2 binding with nanomolar affinity. Agomelatine is also a selective 5-HT2C receptor antagonist with pKis of 6.4 and 6.2 at native (porcine) and cloned, human 5-HT2C receptors, respectively. | ||
M5919 | Ramelteon (TAK-375) | Melatonin Receptor |
TAK-375 | ||
Ramelteon (TAK-375) is a novel melatonin receptor agonist for human MT1 and MT2 receptors and chick forebrain melatonin receptors with Ki of 14 pM, 112 pM and 23.1 pM, respectively. | ||
M8769 | Tasimelteon | Melatonin Receptor |
BMS-214778; VEC-162 | ||
Tasimelteon (BMS-214778) is a Dual Melatonin Receptor Agonist (DMRA) recently approved (Hetlioz) for the treatment of Non-24-hour sleep–wake disorder, a disorder primarily found in the totally blind, where a lack of normal synchronization between the 24-hour light–dark cycle and the endogenous circadian rhythm causes it to drift out of alignment with conventional sleep–wake schedules. |
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