About 7 results found for searched term "MS28" (0.051 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M3768 | Ixabepilone | Microtubule |
| Ixempra, BMS-247550, NSC 710428 | ||
| Ixabepilone (BMS 247550) is an epothilone B analog and nontaxane microtubule-stabilizing compound with clinical activity in a range of solid tumors. | ||
| M5613 | Entrectinib (RXDX-101) | ALK |
| NMS-E628; RXDX-101 | ||
| Entrectinib (RXDX-101) is an orally bioavailable pan-TrkA/B/C, ROS1 and ALK inhibitor with IC50 ranging between 0.1 and 1.7 nM. | ||
| M6515 | BMS 182874 hydrochloride | Others |
| BMS 182874 hydrochloride is a highly selective, orally active non-peptide ET A antagonist. | ||
| M13718 | Onvansertib | PLK |
| PCM-075; NMS-1286937; NMS-P937 | ||
| Onvansertib (PCM-075, NMS-1286937, NMS-P937) is a first-in-class, third-generation, oral, highly selective PLK1 inhibitor that induces tumor cell arrest in the G2/M phase and triggers apoptosis. It has a median IC50=136nM against a variety of CRC cell lines and inhibits xenograft models such as HT-29, HCT-116, and Colo-205 well. | ||
| M21026 | Garenoxacin | Anti-infection |
| T-3811ME, BMS-284756 | ||
| Garenoxacin (T-3811ME, BMS-284756) is a novel des-F(6) quinolone that has been shown to be effective in vitro against a wide range of clinically important pathogens, including gram-positive and gram-negative aerobes and anaerobes. | ||
| M40700 | MS28 | PROTAC |
| MS28 is a PROTAC molecule that targets CDK4/6 and induces ubiquitin ligases in close proximity to Cyclin D1 and CDK4/6 with antitumor activity. | ||
| M41816 | BMS 182874 | Endothelin Receptor |
| BMS 182874 is an orallyactive, highly selective endothelin receptor (ETA receptor) antagonist, with IC50 value of 0.150 μM, Ki of 0.055 μM. | ||
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