About 1 result found for searched term "MS177 " (0.12 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M29378 | MS177 | PROTAC |
| MS177 is an effective and fast-acting EZH2 degrader. MS177 is a PROTAC that consists of a CRBN ligand, linker, and a potent enzymatic EZH2 inhibitor C24 (C24 IC50): 12 nM). MS177 effectively depletes both canonical EZH2–PRC2 and noncanonical EZH2–cMyc complexes. MS177 induces leukaemia cell growth inhibition, apoptosis and cell cycle progression arrest. | ||
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