About 14 results found for searched term "MMP2-IN-1" (0.134 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M58413 | MMP2-IN-1 | MMP |
| MMP2-IN-1 is a moderate potenet MMP2 inhibitor with IC50 of 6.8 µM. MMP2-IN-1 exhibits remarkable antiproliferative activity in certain cancer cells by arresting the cell cycle and inducing apoptosis. | ||
| M25487 | PU02 | 5-HT Receptor |
| NMMP | ||
| PU02 (NMMP) is a potent and selective negative allosteric modulator (NAM) of 5-HT3 receptor, displaying IC50 values of ~1 μM at 5-HT(3)Rs and substantially lower activities at other Cys-loop receptors. PU02 inhibits the proliferation of hepatocellular carcinoma (HepG2) cells associated with G2/M phase cell cycle arrest, and reduced cyclin-dependent kinase (CDK) 4 and cyclin B1/D1 levels. | ||
| M28847 | MMP2-IN-2 | MMP |
| MMP2-IN-2 (compound 42) is a potent and selective MMP-2 (matrix metalloproteinases) inhibitor, with an IC50 of 4.2 μM. MMP2-IN-2 also shows inhibitory activity against MMP-13, MMP-9 and MMP-8, with IC50 values of 12, 23.3, and 25 μM, respectively. | ||
| M28910 | BAY-7598 | MMP |
| BAY-7598 is a potent, orally bioavailable, and selective MMP12 inhibitor probe with IC50s of 0.085, 0.67 and 1.1 nM for human MMP12, murine MMP12, and rat MMP12, respectively. | ||
| M30518 | ARP-100 | MMP |
| ARP-100 is a potent and selective matrix metalloproteinase MMP-2 inhibitor (IC50=12 nM). ARP-100 interacts with S1＇ pocket of MMP-2 and shows anti-invasive properties in an in vitro model of invasion on matrigel. ARP-100 shows the less inhibitory activity towards MMP-1 (>50 μM), MMP-3 (4.5 μM), MMP-7 (>50 μM), and MMP-9 (0.2 μM). | ||
| M30573 | NSC 405020 | MMP |
| NSC 405020 is a specific MMP14 inhibitor. NSC 405020 can directly interact with the hemopexin domain of MMP14. NSC 405020 reduces the expression of full length and active cleaved Notch3 (NICD3). NSC 405020 can be used to research vestibular schwannoma, hemostasis and thrombosis. | ||
| M31127 | Recombinant Human MMP-2 Protein (HEK293, C-6His) | Enzymes & Regulators |
| Matrix Metalloproteinase-2; Gelatinase A | ||
| Recombinant Human MMP-2 (also known as matrix metalloproteinase-2) is an enzyme that in humans is encoded by the MMP2 gene.It belongs to the matrix metalloproteinase (MMP) family. MMP-2 can act on several nonmatrix proteins such as big endothelial 1 and beta-type CGRP promoting vasoconstriction. The proenzyme needs to be activated by APMA for an activated form. | ||
| M40386 | Excisanin A | Others |
| Excisanin A is a potent anticancer agent. Excisanin A inhibits cell proliferation, migration, adhesion and invasion. Excisanin A decreases the expression of MMP-2, MMP-9, p-FAK, p-Src, integrin β1 protein. Excisanin A has the potential for the research of breast cancer. | ||
| M42514 | RXP470.1 | MMP |
| RXP470.1 (RXP-470) is a potent, selective MMP-12 inhibitor with a Ki of 0.2 nM against human MMP-12. | ||
| M42518 | MMP-7-IN-2 | MMP |
| MMP-7-IN-2 is a selective MMP7 inhibitor, with an IC50 of 16 nM. | ||
| M43969 | Recombinant Mouse MMP-12 (HEK293, C-6His) | Enzymes & Regulators |
| Matrix metalloproteinase-12 | ||
| Matrix metalloproteinase-12 (MMP12) contains 4 hemopexin repeats and belongs to the peptidase M10A family. MMP12 may be involved in tissue injury and remodeling and have significant elastolytic activity. | ||
| M43971 | Recombinant Human MMP12 Protein (E. coli) | Enzymes & Regulators |
| Matrix metalloproteinase-12 | ||
| Matrix metalloproteinase-12 (MMP12) is a macrophage-secreted elastase that is highly induced in the liver and lung in response to S. mansoni eggs and contains four hemopexin-like domains. MMP12 is a proteolytic enzyme responsible for the cleavage of plasminogen to angiotensin, which has an angiostatic effect. | ||
| M56723 | BPHA | MMP |
| BPHA is a potent and orally active MMP-2, MMP-9 and MMP-14 inhibitor with IC50s of 12 nM, 16 nM and 17 nM, respectively. | ||
| M56721 | UK-370106 | MMP |
| UK-370106 is a potent and highly selective MMP-3 (IC50 of 23 nM) and MMP-12 (IC50 of 42 nM) inhibitor with >1200-fold higher potency than MMP-1, MMP-2, MMP-9, and MMP-14, and about 100-fold than MMP-13 and MMP-8. | ||
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