About 6 results found for searched term "ML264" (0.125 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M8650 | ML264 | KLF |
| CID-51003603 | ||
| ML264 is a potent and selective inhibitor of Kruppel-like factor 5 (KLF5) expression. | ||
| M24707 | Indusatumab vedotin | Drug-Linker Conjugates for ADC |
| MLN0264; TAK-264 | ||
| Indusatumab vedotin (MLN-0264; AKT-264) is an antibody-drug conjugate (ADC) consisting of the human anti-guanylate cyclase C (GCC) antibody linked to a microtubule-disruptor Monomethyl auristatin . Indusatumab vedotin has anti-proliferative effects on pancreas cancer cell lines. Indusatumab vedotin arrests cell cycle at G2/M phase, and induces apoptosis. | ||
| M19167 | Amaroswerin | NO Synthase |
| Amaroswerin is a bioactive secoiridoid glucoside from Swertia mussotii. Amaroswerin inhibits NO release with an IC50 value of 5.42 μg/mL in RAW264.7 cells. | ||
| M20704 | SR18662 | Others |
| SR18662 is an optimized compund based on ML264 that inhibits Krüppel-like factor 5 (KLF5) with IC50 of 4.4 nM. SR18662 reduces the viability of multiple colorectal cancer cell lines. SR18662 induces apoptosis. | ||
| M29680 | SR18662 | KLF |
| SR18662 is a potent inhibitor of Krüppel-like factor five (KLF5) with an IC50 of 4.4 nM and an analogue of ML264 with improved inhibitory potency against colorectal cancer cells. SR18662 can be used for the study of colorectal cancer. | ||
| M29821 | HS-276 | IRAK |
| HS-276 is an orally active, potent and highly selective TAK1 inhibitor, with a Ki of 2.5 nM. HS-276 shows significant inhibition of TAK1, CLK2, GCK, ULK2, MAP4K5, IRAK1, NUAK, CSNK1G2, CAMKKβ-1, and MLK1, with IC50 values of 8.25, 29, 33, 63, 125, 264, 270, 810, 1280, and 5585 nM, respectively. HS-276 can be used for rheumatoid arthritis (RA) research. | ||
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