About 24 results found for searched term "Lipid 6" (0.125 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M42469 | Lipid 6 | Liposome |
| Lipid 6 is an ionizable amino lipid used for the generation of Lipid nanoparticles (LNPs). | ||
| M42474 | LNP Lipid-6 | Liposome |
| LNP Lipid-6 is an ionizable lipid (amino lipid). | ||
| M4228 | Neferine | NF-κB |
| (-)-Neferine | ||
| Neferine is a bisbenzylisoquinoline alkaloid extracted from Plumbago officinalis, which reduces lipid accumulation and promotes β-oxidation through activation of the AMPK pathway in hepatocytes, and possesses anti-inflammatory, antioxidant, and antipulmonary fibrosis activities. In addition, Neferine potently inhibits NF-κB activation.The affinity Kd value of Neferine for ABCB1 is 0.659 μM.It can be used in studies related to non-alcoholic steatohepatitis (NASH). | ||
| M7822 | Gemfibrozil | PPAR |
| 吉非罗齐; CI-719 | ||
| Gemzil is a PPAR-α activator, which is a lipid-lowering agent. Gemfibrozil is also a nonselective inhibitor of P450, with Ki values of 5.8, 24,69 and 82 μM for CYP2C9, 2C19, 2C8 and 1A2, respectively. | ||
| M13339 | L-Palmitoylcarnitine | Potassium Channel |
| L-palmitoyl carnitine is a long-chain acylcarnitine and fatty acid metabolite that accumulates in the sarcoid during ischemia and disrupts the membrane lipid environment. L-palmitoylcarnitine inhibits KATP channel activity by interacting with Kir6.2 without affecting single channel conductance. | ||
| M21034 | SKI-V | SPHK |
| SKI V is a noncompetitive and potent inhibitor of non-lipid sphingosine kinase with IC50 of 2 μM for GST-hSK. SKI-V also inhibits PI3K with IC50 of 6 μM for hPI3k. SKI-V decreases formation of the mitogenic second messenger sphingosine-1-phosphate (S1P) and induces apoptosis with antitumor activity. | ||
| M21202 | Recombinant Human Lipocalin-2/NGAL/LCN2 (E. coli, C-6His) | Cytokines and Growth Factors |
| Neutrophil gelatinase-associated lipocalin; NGAL | ||
| Human neutrophil gelatinase-associated lipid transport protein (Lipocalin-2/NGAL/LCN2) is produced by the E. coli expression system and the target gene encoding Gln21-Gly198 has a 6His tag at the C-terminus.Protein number: P80188 | ||
| M22435 | DLin-KC2-DMA | Liposome |
| DLin-KC2-DMA is an ionisable cationic lipid (pKa≈6), produces significant siRNA-mediated gene silencing of GAPDH, when binds to lipid nanoparticles (LNP). | ||
| M22502 | ATX-100 | Liposome |
| ATX100 | ||
| ATX-100 is a novel cationic lipid (pKa = 6.38). It has been used in the generation of lipid nanoparticles (LNPs) for the delivery of siRNA. | ||
| M25512 | GL67 pentahydrochloride | Cell Transfection |
| N4-Spermine cholesteryl carbamate pentahydrochloride | ||
| GL67 (N4-Spermine cholesteryl carbamate) (pentahydrochloride) is a cationic lipid. GL67 can be used for nucleic acid agents and vaccines delivery, and gene transfection. | ||
| M27669 | E1231 | Sirtuin |
| 1-{4-[2-(5-Methylfuran-2-yl)quinoline-4-carbonyl]piperazin-1-yl}ethan-1-one | ||
| E1231 is an orally active activator of Sirtuin 1 (SIRT1) (EC50=0.83 μM), to modulate cholesterol and lipid metabolism. E1231 interactes with SIRT1 (KD=9.61 μM) and deacetylated liver X receptor-alpha (LXRα), and increases ATP-binding cassette transporter A1 (ABCA1) expression. E1231 also reduces atherosclerotic plaque development in ApoE-/- mice model. E1231 can be used for research in cholesterol and lipid disorder-related diseases. | ||
| M28693 | UCB9608 | PI3K |
| UCB9608 is a potent, selective and orally active PI4KIIIβ inhibitor, with an IC50 of 11 nM, selective over PI3KC2 α, β, and γ lipid kinases. UCB9608 improves metabolic stability and exhibits excellent pharmacokinetic profile, acts as a potent immunosuppressive agent. | ||
| M29142 | PIP4K-IN-a131 | Others |
| PIP4K-IN-a131 is PIP4K lipid kinases inhibitor, with IC50s of 1.9 µM and 0.6 µM for purified PIP4K2A and PIP4Ks, respectively. PIP4K-IN-a131 exhibits cancer-selective lethality via dual blockade of the lipid kinase PIP4Ks and mitotic pathways. | ||
| M58156 | Recombinant Human PRDX6 Protein (E. coli, N-6His) | Cytokines and Growth Factors |
| Peroxiredoxin-6; 1-Cys Peroxiredoxin; Acidic Calcium-Independent Phospholipase A2 | ||
| Peroxiredoxin 6 (PRDX6) belongs to the thiol-specific antioxidant protein family, it is involved in redox regulation of the cell and can reduce Hydrogen peroxide and short chain organic, fatty acid, and phospholipid hydroperoxides. Peroxiredoxin 6 may regulates phospholipid turnover and protectes against oxidative injury. | ||
| M30555 | 6"-O-Acetylgenistin | Others |
| 6"-O-Acetylgenistin is an isoflavone glycoside isolated from soybeans. 6"-O-Acetylgenistin significantly inhibits lipid peroxidation in rat liver microsome with an IC50 of 10.6 μM. | ||
| M39125 | Coenzyme Q6 | Metabolite/Endogenous Metabolite |
| Coenzyme Q6 (Ubiquinone 30) is an isoprenylated benzoquinone lipid. Coenzyme Q6 exhibits functions in respiratory electron transport and as a lipid antioxidant. Coenzyme Q6 also has antioxidant effects, which can prevent the production of free radicals and oxidative damage. | ||
| M40844 | Recombinant Human Siglec-10 Protein (HEK293, C-Fc) | Receptor Proteins |
| sialic acid-binding Ig-like lectin 10; MGC126774; PRO940 | ||
| Siglec-10 binds sialated proteins and lipids in alpha 2,3 or alpha 2,6 linkage and shows a preference for GT1b gangliosides. This binding can be modulated by cis interactions of Siglec-10 with sialated molecules expressed on the same cell. | ||
| M42457 | Ionizable lipid-1 | Liposome |
| Ionizable lipid-1 is an ionizable lipid (pKa=6.16) that can be used to prepare lipid nanoparticles (LNP) with bilayer structure. | ||
| M49395 | ATX-002 | Solvents & Excipients |
| ATX-002 is an ionizable cationic lipid for RNA drug delivery with theoretical pKa (c-pKa) and measured pKa values of 8.68 and 6.03, respectively. | ||
| M49793 | DPPG sodium | Liposome |
| 1,2-Dipalmitoyl-sn-glycero-3-PG sodium | ||
| DPPG sodium is a phospholipid containing long chain (16:0) palmitic acid inserted in the sn-1 and sn-2 positions.DPPG sodium can be used to prepare micelles, liposomes and other types of artificial membranes. | ||
| M49806 | Genevant CL1 | Liposome |
| Genevant CL1 is an ionizable cationic lipid (lipid 10, pKa=6.3) that can be used in studies related to mRNA lipid nanoparticle (LNP) vaccine delivery. | ||
| M49815 | BAMEA-O16B | Liposome |
| BAMEA-O16B is a lipid nanoparticle that binds disulfide bonds and can efficiently deliver Cas9 mRNA and sgRNA into cells while releasing RNA for genome editing in response to intracellular reducing environments.BAMEA-O16B can be used for gene editing research. | ||
| M58213 | CAY10614 | TLR |
| CAY10614 is a potent TLR4 antagonist. CAY10614 inhibits the lipid A-induced activation of TLR4, with an IC50 of 1.675 μM. | ||
| M58560 | Glucocerebrosides (Soy) | Others |
| Glucosylceramide (GluCer) is a major sphingolipid of plant tissue and, thus, abundant in nature and in dietary food sources. Soybean GluCer was comprised primarily (>98%) of ceramide with 4,8-sphingadiene (d18:2(delta4,delta8)) and alpha- hydroxypalmitic acid (h16:0); the remainder had the same backbone with h18:0, h20:0, h22:0 and h24:0 fatty acids. | ||
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