About 2 results found for searched term "Lifitegrast" (0.12 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M5852 | Lifitegrast | Integrin |
| SAR 1118; Xiidra | ||
| Lifitegrast is an antagonist of integrin lymphocyte function associated antigen-1 (LFA-1). The IC50 of Jurkat T cells to icAM-1 was 2.98nM. Lifitegrast blocks the interaction between LFA-1 and ICAM-1, thereby reducing T cell activity and cytokine secretion. | ||
| M45151 | Lifitegrast sodium | Integrin |
| SAR 1118 sodium; SHP-606 sodium | ||
| Lifitegrast sodium is a potent integrin antagonist that blocks the binding of intercellular adhesion molecule 1 (ICAM-1) to lymphocyte function-associated antigen (LFA-1) and interrupts the T cell-mediated inflammatory cycle. Lifitegrast sodium inhibits the attachment of Jurkat T cells to ICAM-1 with an IC50 of 2.98 nM.May be useful in studies related to dry eye. | ||
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