About 6 results found for searched term "LY294002" (0.133 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M1925 | LY294002 | PI3K |
| NSC 697286; SF 1101 | ||
| LY294002 is a highly selective PI3K inhibitor with IC50 values of 0.31, 0.73, 1.06 and 6.60 μM for PI3Kβ, PI3Kα, PI3Kδ and PI3Kγ respectively. LY294002 also inhibits CK2 with an IC50 of 98 nM. LY294002 is a competitive DNA-PK inhibitor that binds reversibly to the kinase domain of DNA-PK with an IC50 of 1.4 μM. | ||
| M7901 | LY-294,002 hydrochloride | PI3K |
| LY294002 hydrochloride | ||
| LY-294,002 hydrochloride is a potent broad-spectrum PI3K inhibitor with IC50s of 0.5, 0.57, and 0.97 μM for P110α, P110δ, and P110β, respectively; in addition, LY294002 hydrochloride also inhibits CK2, with an IC50 of 98 nM, and can be used in studies related to pancreatic cancer. LY294002 hydrochloride can also inhibit CK2 with an IC50 of 98 nM. | ||
| M3007 | SF1126 | PI3K |
| SF1126 is the RGDS-conjugated precursor of LY294002 and the first-in-class dual PI3K/BRD4 pan-inhibitor with anti-tumor and anti-angiogenic activities. It also induces apoptosis. | ||
| M4852 | LY303511 | mTOR |
| LY303511 is a structural analogue of LY294002, which does not inhibit PI3K, increased homotypic GJIC. | ||
| M7139 | PI 828 | PI3K |
| PI 828 is a pI 3-kinase inhibitor, more potent than LY 294002. | ||
| M9121 | LY303511 hydrochloride | mTOR |
| NV-128; EM 101 hydrochloride | ||
| LY303511 hydrochloride is a structural analogue of LY294002. LY303511 enhances TRAIL sensitivity of SHEP-1 neuroblastoma cells via hydrogen peroxide-mediated mitogen-activated protein kinase activation and up-regulation of death receptors. | ||
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