About 9 results found for searched term "JS-K" (0.117 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M7864 | JS-K | Others |
| Nitric oxide donor; antiproliferative. | ||
| M9558 | JSH-150 | CDK |
| JSH-150 is a potent CDK9 inhibitor with IC50 of 1 nM. | ||
| M10374 | AMG 232 | Mdm2 |
| Navtemadlin ; KRT-232 | ||
| AMG 232 is an extremely potent MDM2 inhibitor (SPR KD = 0.045 nM, SJSA-1 EdU IC50 = 9.1 nM), with remarkable pharmacokinetic properties and in vivo antitumor activity in the SJSA-1 osteosarcoma xenograft model (ED50 = 9.1 mg/kg). *The compound is unstable in solutions, freshly prepared is recommended | ||
| M21228 | WF-47-JS03 | RET |
| WF-47-JS03 is a potent and selective RET kinase inhibitor with more than 500-fold selectivity for the kinase insertion domain receptor (KDR).WF-47-JS03 acts on Ba/F3 cells transfected with KIF5B-RET and LC-2/ad lung cancer cells transfected with CCDC6-RET with IC50s of 1.7 nM and 5.3 nM, respectively. crossed the blood-brain barrier. | ||
| M24947 | Ongericimab | PCSK9 |
| JS002 | ||
| Ongericimab (JS002) is a humanized anti-PCSK9 IgG4ҡ monoclonal antibody for hypercholesterolemia and hyperlipidemia. | ||
| M25196 | Briquilimab | Others |
| JSP-191 | ||
| Briquilimab (JSP-191) is a non-toxic humanized monoclonal antibody targeting CD117 (c-Kit) to deplete hematopoietic stem cell (HSC). Briquilimab has safety to clear host marrow niche space to enable sufficient donor HSC engraftment and immune reconstitution as primary method of severe combined immunodeficiency (SCID). | ||
| M25331 | Tifcemalimab | Others |
| JS004 | ||
| Tifcemalimab (JS004) is a humanized anti-BTLA (B and T lymphocyte attenuation factor) monoclonal antibody. Tifcemalimab blocks the interaction of HVEM-BTLA by binding to BTLA, and thus blocks the inhibitory signaling pathway mediated by BTLA. Tifcemalimab can be used in research of cancer. | ||
| M28916 | BI-0252 | p53 |
| BI-0252 is an orally active, selective MDM2-p53 inhibitor with an IC50 of 4 nM. BI-0252 can induce tumor regressions in all animals of a mouse SJSA-1 xenograft, with concomitant induction of the tumor protein p53 (TP53) target genes and markers of apoptosis. | ||
| M29609 | JS25 | BTK |
| JS25 is a selective and covalent inhibitor of BTK that inactivates BTK with an IC50 value of 5.8 nM by chelating Tyr551. JS25 inhibits cancer cells proliferation, pronounces cell death, and promotes murine xenograft model of Burkitt’s lymphoma. JS25 effectively crosses the blood-brain barrier. | ||
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