About 7 results found for searched term "JNK-1-IN-2" (0.13 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M42126 | JNK-1-IN-2 | JNK |
| JNK-1-IN-2 is a JNK-1 inhibitor (IC50: 33.5 nM). | ||
| M4361 | Polyphyllin-I | JNK |
| Polyphyllin I is a bioactive ingredient extracted from Paris Polyphylla with strong anti-tumor activity. Polyphyllin I is an activator of the JNK signaling pathway and an inhibitor of PDK1/Akt/mTOR signaling. Polyphyllin I induces autophagy, G2/M phase arrest and apoptosis. | ||
| M7582 | SB 239063 | p38 MAPK |
| SB 239063 is a potent and selective p38 MAPK inhibitor (IC50 = 44 nM for p38α). SB 239063 displays > 220-fold selectivity over ERK, JNK1 and other kinases; ~ 3-fold more selective than SB 203580. | ||
| M29643 | YL5084 | JNK |
| YL5084, a covalent JNK inhibitor, exhibits selectivity for JNK2 and JNK3 over JNK1 with IC50s of 70 nM, 84 nM and 2173 nM, respectively. YL5084 exhibits JNK2-independent antiproliferative effects and induces apoptosis in a JNK2-independent manner. | ||
| M42123 | JNK-IN-12 | JNK |
| JNK-IN-12 is a mitochondrial-targeted JNK inhibitor (IC50=66.3 nM), consisting of a mitochondrial-specific cell-penetrating peptide and a specific inhibitor of JNK, SP600125. | ||
| M42127 | JNK2-IN-1 | JNK |
| JNK2-IN-1 is a JNK2 inhibitor (Kds: 79.2 μM). | ||
| M55643 | SKLB-163 | Apoptosis |
| SKLB163 | ||
| SKLB-163 is an orally active inhibitor for Rho GDP-dissociation (RhoGDI). SKLB-163 acts by downregulating RhoGDI, activating JNK-1 signaling pathway and caspase-3, and reducing phosphorylated Akt and p44/42 MAPK. SKLB-163 inhibits highly expressed RhoGDI tumor cell proliferation and migration, and increases radiosensitivity of tumor cells. SKLB-163 induces cancer cell Apoptosis. | ||
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